摘要
放射性心脏病(radiation-induced heart disease,RIHD)是胸部肿瘤患者放射治疗后的一种严重并发症,对接受放射治疗的癌症患者的远期生存造成明显的影响。RIHD的发病机制研究及开发有效的治疗药物是亟待解决的问题,而建立优质的RIHD动物模型是解决这一问题的关键。本文综述了RIHD模型构建的关键因素,包括动物种类选择、射线类型、照射剂量、照射次数、辐射部位和造模时间,以及模型评估方法与成模标准;同时立足DNA损伤、氧化应激反应、炎症反应、线粒体损伤、肾素-血管紧张素-醛固酮系统激活、心肌纤维化等机制总结了RIHD的潜在的发病机制及各机制之间内在关系,为构建RIHD动物模型及RIHD的机制研究提供了参考依据。
Radiation-induced heart disease(RIHD)is a severe complication in patients with thoracic cancer undergoing radiotherapy,with important impacts on long-term survival among cancer survivors.There is an urgent need to investigate the pathogenesis of RIHD and to develop effective therapeutic agents,and the establishment of high-quality RIHD animal models is pivotal to addressing these issues.This review summarizes the critical factors to consider in establishing RIHD animal models,including species selection,radiation type,dosage,fractionation,and target fields,and modeling timeline,along with the evaluation method and success criteria.We also consider the potential pathogenic mechanisms underlying RIHD,including DNA damage,oxidative stress,inflammatory responses,mitochondrial dysfunction,renin-angiotensin-aldosterone system activation,and myocardial fibrosis,as well as their interrelationships.These insights provide a comprehensive reference framework for constructing RIHD animal models and advancing mechanistic investigations into this condition.
作者
刘佳坤
蒋虎刚
刘爱
王夏颖
马静
石杨洋
赵信科
李应东
LIU Jiakun;JIANG Hugang;LIU Ai;WANG Xiaying;MA Jing;SHI Yangyang;ZHAO Xinke;LI Yingdong(School of Traditional Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China)
出处
《中国实验动物学报》
北大核心
2025年第8期1178-1197,共20页
Acta Laboratorium Animalis Scientia Sinica
基金
国家自然科学基金(82360926)。
关键词
放射性心脏病
动物模型
评价标准
机制研究
radiation-induced heart disease
animal models
evaluation criteria
mechanism research
