摘要
脓毒症相关急性肾损伤(S-AKI)是重症患者中常见且致死率较高的并发症,其病理机制复杂,治疗手段有限。随着生物标志物、分子机制及早期诊断技术的不断发展,S-AKI的早期识别和干预逐渐成为研究重点。本文综述S-AKI的基本概念、流行病学、生物标志物、病理生理以及治疗预防方面的进展。旨在为S-AKI的早期诊断与治疗提供新的思路,推动临床和基础研究的进一步发展。
Sepsis-associated acute kidney injury(S-AKI)is a common and highly lethal complication in critically ill patients,with complex pathological mechanisms and limited therapeutic options.With the continuous developments of biomarkers,molecular mechanisms,and early diagnostic techniques,early identification and intervention of S-AKI have gradually become research focal points.This article reviews the progress that was achieved in the basic concepts,epidemiology,biomarkers,pathophysiology,treatment and prevention of S-AKI.This article aims to provide novel insights into the early diagnosis and treatment of S-AKI and promote further development in clinical and basic research.
作者
齐鹏
张颖
张丽萍
QI Peng;ZHANG Ying;ZHANG Liping(First Medical Center of Chinese PLA General Hospital,Beijing,100853,China)
出处
《中华医院感染学杂志》
北大核心
2025年第16期2541-2545,共5页
Chinese Journal of Nosocomiology
关键词
脓毒症
急性肾损伤
进展
生物标志物
病理生理
治疗策略
Sepsis
Acute kidney injury
Progress
Biomarkers
Pathophysiology
Treatment strategies
