摘要
目的:观察汉防己甲素片联合孟鲁司特钠对尘肺病患者呼吸功能、炎性介质及血清基质金属蛋白酶-9(MMP-9)、碱性成纤维细胞生长因子(bFGF)水平的影响。方法:选择我院2023年1月至2024年6月期间收治的尘肺病患者120例,采用随机数字表法将患者分为对照组(孟鲁司特钠治疗,n=60)和研究组(汉防己甲素片联合孟鲁司特钠治疗,n=60)。对比两组肺功能指标[第一秒钟用力呼气容积(FEV_(1))、用力肺活量(FVC)、最大通气量(MVV)]、6分钟步行试验(6MWT)距离、圣乔治呼吸问卷(SGRQ)评分、改良英国医学研究委员会呼吸困难(mMRC)指数、炎性介质[胱抑制素C(Cys C)、白介素2受体(IL-2R)、C反应蛋白(CRP)]水平和血清MMP-9、b FGF水平。同时观察不良反应情况。结果:研究组治疗6个月后FEV1、FVC、MVV、6MWT距离高于对照组,SGRQ评分、mMRC指数、Cys C、IL-2R、CRP、MMP-9、bFGF低于对照组(P<0.05)。两组不良反应发生率比较无明显差异(P>0.05)。结论:汉防己甲素片联合孟鲁司特钠治疗尘肺病患者,可有效改善患者呼吸功能,提高其运动耐力,调节炎性介质及血清MMP-9、bFGF水平,安全可靠。
Objective:To observe the effects of tetrandrine tablets combined with montelukast sodium on respira tory function,inflammatory mediators,serum matrix metalloproteinase-9(MMP-9)and basic fibroblast growth factor(bFGF)levels in pneumoconiosis patients.Methods:120 pneumoconiosis patients who were admitted to our hospital from January 2023 to June 2024 were selected,they were divided into control group(montelukast sodium treatment,n=60)and study group(tetrandrine tablets combined with montelukast sodium treatment,n=60)by random number table method.The pulmonary function indexes[first second forced expiratory volume(FEV_(1)),forced vital capacity(FVC),maximum ventilation volume(MVV)],6-minute walking test(6MWT)disitance,St.George Respiratory Questionnaire(SGRQ)score,Improved Medical Research Council Dyspnea(mMRC)index,and inflammatory mediators[Cystatin C(Cys C),interleukin-2 receptor(IL-2R),C-reactive protein(CRP)]and serum MMP-9,bFGF levels were compared between the two groups.The occurrence of adverse reactions were observed.Results:FEV,FVC,MVV,6MWT distance in the study group at 6 months after treatment were higher than those in the control group,and SGRQ score,mMRC index,CysC,IL-2R,CRP,MMP-9,bFGF were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Tetrandrine tablets combined with montelukast sodium in the treatment of pneumoconiosis patients can effectively improve respiratory function,increase exercise endurance,regulate inflammatory mediators and serum MMP-9,bFGF levels,which is safe and reliable.
作者
林阳坤
伍定辉
苏伟明
LIN Yang-kun;WU Ding-hui;SU Wei-ming(Department of Pulmonary,Xinglin Branch of Xiamen University Affiliated First Hospital,Xiamen,Fujian,361000,China)
出处
《现代生物医学进展》
2025年第15期2458-2464,共7页
Progress in Modern Biomedicine
基金
厦门市卫生指导性项目(3502Z20214ZD3011)。
