摘要
泌尿生殖道沙眼衣原体(Chlamydia trachomatis,Ct)感染的临床过程隐匿、症状轻微、迁延难愈,其慢性持续感染状态和并发症给患者和社会带来了沉重的负担。大量研究表明,作为一线疗法的抗生素可能不足以完全清除泌尿生殖道感染的Ct。此外,抗生素治疗可以导致Ct耐药,并可增加体内菌群失调的风险,因此十分有必要开发新的Ct抑制剂。本综述对近年Ct抑制剂的研究进展进行总结,以期为泌尿生殖道Ct感染的基础研究和临床治疗提供参考。
Genitourinary tract infections caused by Chlamydia trachomatis(Ct)are characterized by their insidious onset,mild symptoms,and prolonged disease course,making them challenging to treat effectively.Chronic persistent infections and associated complications impose a significant burden on both patients and society.Numerous studies have shown that relying solely on antibiotics as first-line therapy may not be sufficient to completely eradicate urogenital Ct infections.Additionally,antibiotic use can lead to the development of Ct resistance and disrupt the body's microbial balance.Therefore,the development of novel Ct inhibitors is crucial.This review summarizes recent advances in research on Ct inhibitors,aiming to provide a valuable reference for both basic research and clinical treatment of urogenital Ct infections.
作者
丘秀枫
项佑富
卢普扬
李龙年
曾招林
尤聪
Qiu Xiufeng;Xiang Youfu;Lu Puyang;Li Longnian;Zeng Zhaolin;You Cong(The First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China;Department of Dermatology,the First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China)
出处
《中华微生物学和免疫学杂志》
北大核心
2025年第8期701-706,共6页
Chinese Journal of Microbiology and Immunology
基金
江西省教育厅科学技术研究项目(GJJ201519)。
关键词
沙眼衣原体
抑制剂
致病因子
Chlamydia trachomatis
Inhibitors
Pathogenic factors
