摘要
目的探究本院儿科肺部感染抗菌药物使用情况及其用药合理性。方法回顾性分析106例儿科肺部感染患儿的临床资料,分析不同抗菌药物类型的占比情况、联合用药情况、抗菌药物过敏情况及抗菌药物处方中不合理用药情况。结果106份处方中,抗菌药物用药总例次为198例次,其中大环内酯类16例次,占比8.08%;β-内酰胺类35例次,占比17.68%;头孢呋辛45例次,占比22.73%;哌拉西林68例次,占比34.34%;美罗培南14例次,占比7.07%;阿米卡星20例次,占比10.10%。其中哌拉西林抗菌药物使用占比高于其他类型抗菌药物。106份抗菌药物处方中,单一用药35份,占比33.02%;二联用药50份,占比47.17%;三联用药21份,占比19.81%。抗菌药物处方中二联用药占比高于其他类型联合用药。106例患儿中,发生皮疹4例,占比3.77%;水肿2例,占比1.89%;瘙痒1例,占比0.94%;胃肠反应3例,占比2.83%;嗜睡2例,占比1.89%;头晕3例,占比2.83%,共15例患儿发生过敏反应,发生率为14.15%。106份抗菌药物处方中,品种选取不合理2份,占比1.89%;用药剂量不合理1份,占比0.94%;用药频次不合理2份,占比1.89%;用药疗程不合理4份,占比3.77%;联合用药不合理12份,占比11.32%;药物更换不合理1份,占比0.94%;病房记录内无用药分析1份,占比0.94%。其中联合用药不合理的占比高于其他不合理用药类型。结论本院儿科肺部感染使用抗菌药物存在一定的不合理情况,临床应强化抗菌药物使用,提升药物使用的合理性及安全性。
Objective To explore the antimicrobial drug use and rationality in pediatric pulmonary infections at our hospital.Methods A retrospective analysis was conducted on the clinical data of 106 pediatric patients with pulmonary infections.Analysis of the proportion of different types of antimicrobial drugs,the use of combination therapy,allergy to antibacterial drugs,and irrational use of antibacterial drugs in prescriptions.Results Among the 106 prescriptions,the total number of antimicrobial drug use was 198 cases/times,in which macrolides accounted for 16 cases/times,representing 8.08%;35 cases ofβ-lactams,representing 17.68%;cefuroxime accounted for 45 cases/times,representing 22.73%;piperacillin accounted for 68 cases/times,representing 34.34%;meropenem accounted for 14 cases/times,representing 7.07%;and amikacin accounted for 20 cases/times,representing 10.10%.Among these,the proportion of piperacillin antibiotic use was higher than that of other types of antimicrobial drugs.Among the 106 antimicrobial drug prescriptions,single-drug use accounted for 35 prescriptions(33.02%),dual-drug use for 50 prescriptions(47.17%),and triple-drug use for 21 prescriptions(19.81%).The proportion of dual-drug use in antimicrobial prescriptions was higher than other types of combination therapy.Among the 106 pediatric patients,4 cases of rash occurred,accounting for 3.77%;2 cases of edema,accounting for 1.89%;1 case of itching,accounting for 0.94%;3 cases of gastrointestinal reactions,accounting for 2.83%;2 cases of somnolence,accounting for 1.89%;and 3 cases of dizziness,accounting for 2.83%.A total of 15 pediatric patients experienced allergic reactions,with an incidence rate of 14.15%.Among the 106 antimicrobial drug prescriptions,2 cases involved inappropriate selection of drug types,accounting for 1.89%;1 case involved inappropriate dosage,accounting for 0.94%;2 cases involved inappropriate dosing frequency,accounting for 1.89%;4 cases involved inappropriate treatment duration,accounting for 3.77%;12 cases involved inappropriate combination therapy,accounting for 11.32%;1 case involved inappropriate drug substitution,accounting for 0.94%;and 1 case involved no medication analysis in the ward records,accounting for 0.94%.Among these,the proportion of inappropriate combination therapy was higher than that of other types of inappropriate drug use.Conclusion There are certain unreasonable situations in the use of antimicrobial drugs for pediatric pulmonary infections of our hospital.In clinical practice,the use of antimicrobial drugs should be strengthened to enhance the rationality and safety of drug use.
作者
林霖
LIN Lin(Pharmacy Department,Nantong Town Health Center,Minhou County,Fuzhou 350111,China)
出处
《中国现代药物应用》
2025年第19期135-138,共4页
Chinese Journal of Modern Drug Application
关键词
儿科
肺部感染
病原菌
抗菌药物
Pediatrics
Pulmonary infections
Pathogenic bacteria
Antimicrobial drug
