摘要
巨噬细胞是先天免疫系统的核心效应细胞,其表型极化(如M1/M2)受肿瘤微环境中多种因素的精密调控。本文系统综述肿瘤微环境中调控M2型巨噬细胞极化的五大关键信号通路(NF-κB、PI3K/Akt、JAK/STAT、MAPK、Notch),解析其分子机制及在肿瘤进展中的作用。研究进一步探讨靶向干预策略(如小分子抑制剂、代谢重编程、纳米载药系统)在逆转M2极化及抑制肿瘤血管生成、免疫逃逸中的潜在价值,为开发基于巨噬细胞表型调控的精准治疗提供理论依据。
Macrophages are core effector cells of the innate immune system,and their phenotypic polarization(e.g.,M1/M2)is precisely regulated by various factors within the tumor microenvironment.This article systematically reviews five key signaling pathways—NF-κB,PI3K/Akt,JAK/STAT,MAPK,and Notch—that regulate M2-type macrophage polarization,and analyzes their molecular mechanisms and roles in tumor progression.Furthermore,the study explores the potential of targeted intervention strategies,such as small-molecule inhibitors,metabolic reprogramming,and nanodrug delivery systems,in reversing M2 polarization and inhibiting tumor angiogenesis and immune escape.These insights provide a theoretical foundation for the development of precision therapies based on macrophage phenotypic regulation.
作者
侯亚超
金鑫鑫
张俊丽
武文娟
Hou Yachao;Jin Xinxin;Zhang Junli;Wu Wenjuan(School of Laboratory Medicine,Bengbu Medical University,Bengbu,Anhui 233000,China;The Third People's Hospital of Bengbu,Bengbu,Anhui 233000,China)
出处
《齐齐哈尔医学院学报》
2025年第16期1588-1595,共8页
Journal of Qiqihar Medical University
基金
安徽省教育厅自然科学重点项目(2022AH051452、2022AH051485)。
