摘要
目的探讨血清HIF-1α、Bcl-2与可手术切除的局部晚期食管鳞癌患者TP方案化疗反应的相关性。方法选取2022年1月—2024年6月在本院拟接受TP方案化疗的105例局部晚期食管鳞癌患者作为研究对象,根据患者化疗2个周期后的化疗反应分为有反应组(56例)和无反应组两(49例)组。对比两组的基本资料和实验室指标水平,重点分析HIF-1α、Bcl-2与患者化疗反应的相关性。结果105例患者化疗2个周期后,56例有反应(完全缓解、部分缓解),49例无反应(疾病稳定、疾病进展)。无反应组Ⅳ期、淋巴结转移占比,化疗前血清VEGF、CEA、HIF-1α、Bcl-2水平高于有反应组(P<0.05)。Logistic多元回归分析显示,可手术切除的局部晚期食管鳞癌患者TP方案化疗反应受血清CEA、HIF-1α、Bcl-2影响(OR>1,P<0.05),经点二列相关性分析,患者化疗无反应风险与血清HIF-1α、Bcl-2水平呈正相关关系(P<0.05)。绘制ROC曲线,血清HIF-1α联合Bcl-2能预测患者化疗无反应风险。结论可手术切除的局部晚期食管鳞癌患者TP方案化疗无反应风险与化疗前血清HIF-1α、Bcl-2水平呈正相关关系,二者联合可预测患者早期化疗无反应风险。
Objective To investigate the correlation between serum HIF-1α,Bcl-2 and TP chemotherapy response in patients with locally advanced esophageal squamous cell carcinoma(ESCC)suitable for surgical resection.Methods A total of 105 patients with locally advanced ESCC who were scheduled to receive TP regimen chemotherapy in our hospital from January 2022 to June 2024 were selected as study subjects.According to the chemotherapy response after 2 cycles of chemotherapy,the patients were divided into response group and non-response group.The basic data and laboratory index levels of the two groups were compared,and the correlation between HIF-1α,Bcl-2 and chemotherapy response was analyzed.Results After 2 cycles of chemotherapy,56 out of 105 patients showed a response(complete remission,partial remission),while 49 had no response(disease stability,disease progression).The proportion of stageⅣand lymph node metastasis in the non-response group,as well as the levels of serum VEGF,CEA,HIF-1α,and Bcl-2 before chemotherapy,were higher than those in the response group(P<0.05).Logistic multivariate regression analysis showed that the response to TP chemotherapy in patients with locally advanced ESCC suitable for surgical resection was affected by serum CEA,HIF-1αand Bcl-2(OR>1,P<0.05).According to point-biserial correlation analysis,the risk of chemotherapy non-response in patients was positively correlated with serum HIF-1αand Bcl-2 levels(P<0.05).ROC curve analysis showed that serum HIF-1αcombined with Bcl-2 could predict the risk of chemotherapy non-response in patients.Conclusions The risk of non-response to TP chemotherapy in patients with locally advanced ESCC suitable for surgical resection is positively correlated with the levels of serum HIF-1αand Bcl-2 before chemotherapy.The combination of the two can predict the risk of non-response to early chemotherapy.
作者
刘璐璐
张钧硕
赵得堡
屈中玉
张凯
Liu Lulu;Zhang Junshuo;Zhao Debao;Qu Zhongyu;Zhang Kai(Department of Oncology,Nanyang Central Hospital,Nanyang,Henan 473000,China)
出处
《齐齐哈尔医学院学报》
2025年第16期1520-1524,共5页
Journal of Qiqihar Medical University
基金
河南省医学科技攻关计划联合共建项目(LHGJ20230972)。
关键词
食管鳞癌
局部晚期
化疗
反应
缺氧诱导因子1Α
B细胞淋巴瘤2
Esophageal squamous cell carcinoma
Locally advanced
Chemotherapy
Response
Hypoxia-inducible factor-1α
B-cell lymphoma 2
