摘要
传统的观察性研究显示,多种病理状态和生活方式与髋关节骨性关节炎(HOA)的发生与发展密切相关。但受限于观察性研究的局限性,无法准确判断这些因素与HOA的因果关系。基于全基因组关联研究的孟德尔随机化(MR)研究方法近年来被广泛运用于医学领域的病因探索,其遗传变异随机性和时序优先性的独特优势避免了传统观察研究中的混杂偏倚等不利条件。目前已有多项利用MR的研究探索了多种病理状态和生活方式与HOA的因果关系,现对基于MR的HOA病因学研究进展进行综述。
Traditional observational studies have shown that a variety of pathological conditions and lifestyles are closely related to the occurrence and development of hip osteoarthritis(HOA).However,due to the limitations of observational studies,it is not possible to accurately determine the causal relationship between these factors and HOA.In recent years,the Mendelian randomization(MR)method based on genome-wide association study has been widely used in the etiological exploration of the medical field,and its unique advantages of randomness of genetic variation and time series priority can avoid the disadvantages of confounding bias in traditional observational studies.At present,a number of studies using Mendelian randomization have explored the causal relationship between various pathological states,lifestyle and HOA,and this article intends to review the research progress on the etiology of HOA based on Mendelian randomization.
作者
孟思宇
杨柳
阎晓霞
MENG Siyu;YANG Liu;YAN Xiaoxia;KABYLSERIK Aibota(College of Orthopedics and Traumatology,Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China;Luoyang Orthopedic-Traumatological Hospital of Henan Province,Zhengzhou 457016,China;Xinjiang Medical University,Urumqi 830054,China)
出处
《陕西医学杂志》
2025年第9期1279-1284,共6页
Shaanxi Medical Journal
基金
国家中医药管理局青年岐黄学者培养项目(国中医药人教函〔2022〕256号)
河南省科技发展计划项目(232102310423)
河南省中医药科学研究专项课题(2022ZYZD14,2024ZY2115)。
