摘要
目的使用静息态功能磁共振成像(rs-fMRI)研究乳腺癌患者δ-连环蛋白不同表达状态对化疗前后脑网络变化的影响。方法选取经病理确诊且未接受首次化疗的乳腺癌患者66例,根据δ-连环蛋白表达水平分为高表达(DH)组(n=31)和低表达(DL)组(n=35)。在化疗前后进行rs-fMRI扫描,计算脑小世界网络属性,包括节点局部效率(NE)、介数中心性(BC)、度中心性(DC)参数,并统计分析化疗前后患者脑小世界网络属性的变化。结果DL组和DH组化疗前后纵向对比网络指标小世界系数(σ)、特征路径长度(λ)、簇系数(γ)、局部聚类系数(Cp)、平均最短路径长度(Lp)、全局效率(Eg)、局部效率(Eloc)差异无统计学意义(P>0.05)。DL组中,化疗后NE值在左侧嗅皮质、双侧眶内额上回、右侧回直肌、左侧尾状核下降,在双侧中央沟盖、左侧顶上回、右侧颞上回及颞极右侧颞上回上升。DH组中,化疗后NE值在双侧补充运动区、右侧顶下缘角回、右侧颞上回下降,在左侧豆状苍白球上升。DL组化疗后BC值在左侧距状裂周围皮层、右侧舌回及左侧尾状核下降,在左侧内侧额上回上升。DH组化疗后BC值在右侧补充运动区、右侧尾状核下降,在右侧后扣带回和左侧豆状苍白球上升。DL组化疗后DC值在左侧补充运动区、右侧回直肌、左侧尾状核下降,在右侧岛盖部额下回、右侧中央沟盖、右侧颞极颞上回、右侧颞上回、左侧顶上回、左侧顶下缘角回及双侧缘上回上升。DH组化疗后DC值在左侧中央前回、双侧补充运动区、左侧梭状回、右侧顶下缘角回及右侧颞上回下降,在左侧豆状苍白球上升。结论乳腺癌患者δ-连环蛋白的高表达可能进一步加重化疗对脑网络的损伤,主要涉及运动和认知相关脑区。
Objective To investigate the impact of different δ-catenin expression levels on brain small-world network alterations before and after chemotherapy in breast cancer patients using resting-state functional MRI(rs-fMRI).Methods A total of 66 breast cancer patients who were pathologically diagnosed and did not receive the first chemotherapy were included and divided into the high-expression(DH)group(n=31)and the low-expression(DL)group(n=35)according to the expression level of δ-catenin.rs-fMRI were performed before and after chemotherapy respectively to calculate the attributes of the brain small-world network,including parameters such as node local efficiency(NE),betweenness centrality(BC),degree centrality(DC)and the changes in the attributes of the brain small-world network of patients before and after chemotherapy were analyzed.Results There was no statistically significant difference in the longitudinal comparison of network indicators such as small-world coefficient(σ),characteristic path length(λ),cluster coefficient(γ),local clustering coefficient(Cp),average shortest path length(Lp),global efficiency(Eg),and local efficiency(Eloc)before and after chemotherapy between the DL group and the DH group(P>0.05).In the DL group,post-chemotherapy NE values was decreased in the left olfactory cortex,bilateral orbital superior frontal gyri,right gyrus rectus,and left caudate nucleus,while increased in the bilateral central operculum,left superior parietal gyrus,right superior temporal gyrus,and temporal pole of the right superior temporal gyrus.In the DH group,post-chemotherapy NE values was decreased in the bilateral supplementary motor area and right angular gyrus,and right superior temporal gyrus,but increased in the left globus pallidus.Post-chemotherapy BC values in the DL group was decreased in the left pericalcarine cortex,right lingual gyrus,and left caudate nucleus,and increased in the left medial superior frontal gyrus.In the DH group,post-chemotherapy BC values was decreased in the right supplementary motor area and right caudate nucleus,while increased in the right posterior cingulate gyrus and left globus pallidus.Post-chemotherapy DC values in the DL group was decreased in the left supplementary motor area,right gyrus rectus,and left caudate nucleus,but increased in the right opercular part of the inferior frontal gyrus,right central operculum,right temporal pole of the superior temporal gyrus,right superior temporal gyrus,left superior parietal gyrus,left angular gyrus,and bilateral supramarginal gyri.In the DH group,post-chemotherapy DC values was decreased in the left precentral gyrus,bilateral supplementary motor areas,left fusiform gyrus,right angular gyrus,and right superior temporal gyrus,while increased in the left globus pallidus.Conclusion The high expression of δ-catenin may further aggravate the damage of chemotherapy to the brain small-world network of breast cancer patients,mainly involving motor and cognition-related brain regions.
作者
姚容容
薛明团
YAO Rongrong;XUE Mingtuan(Chifeng College Training Base,Jinzhou Medical University,Jinzhou,Liaoning 121000,China;Department of Function,Inner Mongolia Arun Banner People’s Hospital,Hulunbuir,Inner Mongolia 162750,China;Department of MR,Affiliated Hospital of Chifeng University,Chifeng,Inner Mongolia 024000,China)
出处
《重庆医学》
2025年第8期1841-1847,共7页
Chongqing Medical Journal
基金
内蒙古自治区公立医院联合基金科技重大项目(2024GLLH1007)
内蒙古自治区公立医院联合基金科技一般项目(2024GLLH1021)。
关键词
乳腺癌
脑小世界网络
δ-连环蛋白
磁共振成像
breast cancer
brain small-world network
δ-catenin
magnetic resonance imaging
