摘要
目的探究非剥脱点阵1565 nm激光联合强脉冲光对痤疮后红斑及皮肤屏障功能的影响。方法选取2021年3月—2024年3月于我院就诊的痤疮后红斑(PAE)患者156例,依据患者就诊意愿,分为对照组(n=76)和联合组(n=80),对照组行非剥脱点阵激光治疗,联合组在对照组基础上增加强脉冲光治疗。利用R语言软件,采用卡钳匹配方法对两组患者进行倾向性评分匹配,按照1∶1的比例进行匹配,最终两组各包含50例患者。比较两组患者临床疗效及治疗后患者红斑指数、皮肤屏障功能,包括经皮水分丢失(TEWL)值、pH、a值、乳酸刺激实验得分、粘脱蛋白质含量、角质层含水量,并比较患者自我满意度。双重差分全模型分析联合治疗对患者自我满意度评分和红斑指数的改善作用。结果治疗后2个月,联合组的临床总有效率(98.00%)显著高于对照组(78.00%);红斑指数(185.53±36.65比216.05±42.59)、TEWL(18.23±3.12比19.75±3.09)、a值(14.98±1.83比19.63±2.18)、乳酸刺激实验得分(1.85±0.75比3.28±1.10)、粘脱蛋白质含量(29.23±6.38比35.05±7.26)均显著低于对照组,角质层含水量(49.26±4.98比38.32±4.82)显著高于对照组;患者自我满意度评分(4.63±1.75比3.75±1.59)显著高于对照组,差异均有统计学意义(均P<0.05)。双重差分模型分析结果显示,联合组自我满意度评分在治疗后上升的幅度比对照组多1.367分,红斑指数下降幅度比对照组多12.167,治疗效果显著。结论PAE患者经非剥脱点阵1565 nm激光联合强脉冲光治疗后,红斑指数下降,皮肤屏障功能提高,自我满意度评分升高。
Objective To explore the effect of 1565 nm non-ablative fractional laser combined with intense pulsed light on post-acne erythema and skin barrier function.Methods A total of 156 patients with post acne erythema(PAE)who were treated in our hospital from March 2021 to March 2024 were screened.Patients were divided into control group(n=76)and combination group(n=80)according to their willingness to the treatment.The control group received 1565 nm non-ablative fractional laser treatment,while the combination group received additional intense pulsed light therapy on top of the control treatment.Using R software,propensity score matching was performed between the two groups using the caliper matching method at a 1∶1 ratio,resulting in 50 patients in each group.The clinical efficacy,erythema index,and skin barrier function,including transdermal water loss(TEWL),pH,a value,lactate acid sting test score,protein content in the tape strip,stratum corneum water content and self-satisfaction of patients were compared between the two groups after the treatment.Difference-in-differences model was used to analyze the effects of combined therapy on self-satisfaction score and erythema index.Results Two months after the treatment,the total effective rate of the combined group(98.00%)was significantly higher than that of the control group(78.00%).The erythema index(185.53±36.65 vs.216.05±42.59),TEWL(18.23±3.12 vs.19.75±3.09)and a value(14.98±1.83 vs.19.63±2.18),lactic acid sting test score(1.85±0.75 vs.3.28±1.10),and protein content in the tape strip(29.23±6.38 vs.35.05±7.26)were significantly lower in the combined group than in control group.In contrast,both stratum corneum water content and self-satisfaction score were significantly higher in the combined group than in the controls(49.26±4.98 vs.38.32±4.82 for water content;4.63±1.75 vs.3.75±1.59 for satisfaction score.P<0.05 for both).The results of difference-in-differences analysis showed that the increase in self-satisfaction scores after treatment was 1.367 points higher in the combination group than in the control group,and the reduction in erythema index was 12.167 points greater,indicating a significant therapeutic effect.Conclusions Following treatment with 1565 nm non-ablative fractional laser combined with intense pulsed light,patients show a reduction in erythema index,improvement in skin barrier function and patient self-satisfaction scores.
作者
郑永青
焦志刚
任书娟
汤腾雁
ZHENG Yongqing;JIAO Zhigang;REN Shujuan;TANG Tengyan(Yellow River Sanmenxia Hospital Affiliated to Henan University of Science and Technology,Sanmenxia 472000,China)
出处
《皮肤性病诊疗学杂志》
2025年第7期502-511,共10页
Journal of Diagnosis and Therapy on Dermato-venereology
关键词
痤疮后红斑
非剥脱点阵激光
强脉冲光
皮肤屏障功能
post-acne erythema
non-ablative fractional laser
intense pulsed light
skin barrier function
