摘要
目的:观察强脉冲光(IPL)联合非剥脱点阵激光(NAFL)预防术后病理性瘢痕形成的早期疗效及对炎症因子的干预研究。方法:选择我院2022年3月至2024年9月收治的93例术后病理性瘢痕形成患者,采用随机数字表法将患者分为对照A组(硅酮凝胶治疗,n=31)、对照B组(对照A组的基础上接受NAFL,n=31)和研究组(对照B组的基础上接受IPL,n=31)。对比三组的临床疗效、简易生活质量量表(SF-36)、温哥华瘢痕量表(VSS)、炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]水平和不良反应情况。结果:研究组的临床总有效率高于对照A组和对照B组(P<0.05)。对照A组、对照B组、研究组治疗后SF-36依次升高,VSS依次下降(P<0.05)。对照A组、对照B组、研究组治疗后CRP、IL-6、TNF-α依次下降(P<0.05)。三组不良反应发生率组间对比无差异(P>0.05)。结论:IPL联合NAFL预防术后病理性瘢痕形成,可有效淡化瘢痕,降低炎症因子水平,提高患者的生活质量,且安全可靠。
Objective:To observe the early efficacy of intense pulsed light(IPL)combined with non-ablative fractional laser(NAFL)in preventing postoperative pathological scar formation and intervention of inflammatory factors.Methods:93 patients with postoperative pathological scar formation who were admitted to our hospital from March 2022 to September 2024 were selected,they were divided into control group A(silicone gel treatment,n=31),control group B(NAFL on the basis of control group A,n=31)and study group(IPL on the basis of control group B,n=31)using the random number table method.The clinical efficacy,simple quality of life scale(SF-36),vancouver scar scale(VSS),inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)],and adverse reactions among three groups were compared.Results:The clinical total effective rate in the study group were higher than those in the control group A and control group B(P<0.05).SF-36 increased sequentially and VSS decreased sequentially in control group A,control group B,and study group after treatment(P<0.05).CRP,IL-6,and TNF-αdecreased sequentially in control group A,control group B,and study group after treatment(P<0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion:IPL combined with NAFL in preventing postoperative pathological scar formation,can effectively reduce scar formation,reduce inflammatory factors levels,improve patients'quality of life,and be safe and reliable.
作者
田利民
余艳琴
张阳
杨新颖
王梦婕
图雅噶尔
陈浩东
杨越楠
TIAN Li-min;YU Yan-qin;ZHANG Yang;YANG Xin-ying;WANG Meng-jie;TU Ya-gaer;CHEN Hao-dong;YANG Yue-nan(Department of Dermatology,First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou,Inner Mongolia,014010,China;Clinical Epidemiology Research Center,First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou,Inner Mongolia,014010,China)
出处
《现代生物医学进展》
2025年第13期2181-2187,共7页
Progress in Modern Biomedicine
基金
内蒙古自治区卫生健康委员会公立医院科研联合基金科技项目(2024GLLH0542)
包头医学院科学研究发展基金项目(BYJJ-GCJH202519)。
关键词
强脉冲光
非剥脱点阵激光
病理性瘢痕
早期疗效
炎症因子
Intense pulsed light
Non-ablative fractional laser
Pathological scar
Early efficacy
Inflammatory factors
