摘要
目的:制备美洲大蠊复合喷膜剂并优化处方,考察其对大鼠创面修复的作用。方法:以喷膜剂的喷雾效果、成膜时间、保湿效果和膜性能为评价指标,对成膜材料的种类及用量进行单因素考察。采用响应面法进一步优化喷膜剂中各组分的配比,建立大鼠皮肤创面模型评价其创面修复作用。结果:确定成膜材料为白及胶(BSP)、聚乙烯吡咯烷酮K30(PVPK30)、泊洛沙姆188(P188),增塑剂为甘油,防腐剂为苯甲酸,优化得到美洲大蠊复合喷膜剂最优处方为5.0%PVPK30、2.0%P188、0.7%BSP、3.0%美洲大蠊提取物、4.0%甘油和0.1%苯甲酸。创面修复结果显示,喷膜剂能显著促进创面愈合。结论:优化后的美洲大蠊复合喷膜剂制备工艺稳定、成膜性好,对大鼠皮肤急性创面具有良好的修复作用。
Objective:To prepare a Periplaneta americana composite spray film,optimize its formulation,and assess its efficacy in wound healing of rats.Methods:Single-factor experiments were conducted to screen film-forming excipients based on evaluation indices including spray atomization performance,film-forming time,moisturizing capacity,and mechanical properties of the film.The formulation ratios were further optimized by response surface methodology.A rat skin wound model was established to evaluate the wound healing effect of the optimized spray film.Results:The optimal film-forming excipients were determined to be Bletilla striata polysaccharide(BSP),polyvinylpyrrolidone K30(PVPK30),and poloxamer 188(P188),with glycerol as the plasticizer and benzoic acid as the preservative.The optimized formulation comprised 5.0%PVPK30,2.0%P188,0.7%BSP,3.0%P.americana extract,4.0%glycerol,and 0.1%benzoic acid.The wound healing study showed that the spray film significantly promoted wound closure and healing in rats.Conclusion:The optimized P.americana composite spray film demonstrated stable preparation technology,excellent film-forming ability,and significant promoting effects on acute skin wound healing in rats.
作者
张敬宇
陈忠泽
李开伶
何荣茂
赵志涛
杨永寿
肖培云
Zhang Jingyu;Chen Zhongze;Li Kailing;He Rongmao;Zhao Zhitao;Yang Yongshou;Xiao Peiyun(College of Pharmacy,Dali University,Dali,Yunnan 671000,China;Periplaneta americana Industrial Development Engineering Research Center,Dali,Yunnan 671000,China)
出处
《大理大学学报》
2025年第8期11-19,共9页
Journal of Dali University
基金
云南省专家工作站资助项目(202405AF140044)
云南省地方本科高校基础研究联合专项资金项目(202401BA070001-007)
云南省科技厅基础研究计划项目(202501AS070162)。
关键词
美洲大蠊
喷膜剂
创面修复
白及胶
响应面法
Periplaneta americana
spray film
wound healing
Bletilla striata polysaccharide
response surface methodology
