摘要
目的探究小儿急性支气管炎患儿服用小儿咳喘颗粒治疗的效果。方法选取80例小儿急性支气管炎患儿为研究对象,按数字表随机排序0~80号,单数序号患儿采用孟鲁司特钠片治疗(40例,对照组),双数序号患儿服用孟鲁司特钠片与小儿咳喘颗粒治疗(40例,观察组),同时两组均给予常规方案治疗。对比两组症状改善用时、炎性因子水平、不良反应发生情况、肺功能指标及免疫功能水平。结果观察组哮鸣音缓解用时(2.75±0.21)d、咳嗽缓解用时(2.86±0.18)d、咳痰缓解用时(1.68±0.25)d、喘息缓解用时(1.85±0.25)d均短于对照组的(5.25±0.21)、(4.65±0.12)、(3.68±0.35)、(3.38±0.19)d(P<0.05)。治疗后,观察组C反应蛋白、血清肿瘤坏死因子-α、白细胞介素-8、白细胞介素-10水平均低于对照组(P<0.05)。观察组不良反应发生率7.50%低于对照组的25.00%(P<0.05)。治疗后,观察组呼气峰值流速、用力肺活量、第1秒用力呼气容积/用力肺活量高于对照组(P<0.05)。治疗后,观察组NK细胞、CD4^(+)、CD8^(+)水平改善较对照组更为显著(P<0.05)。结论小儿急性支气管炎患儿服用小儿咳喘颗粒治疗,可以促使患儿症状迅速改善,降低患儿炎性因子水平,提升患儿肺功能,降低不良反应。
Objective To explore the effect of Xiaoer Kechuan Granules in the treatment of acute bronchitis in children.Methods 80 children with acute bronchitis were selected as the research subjects.The patients were randomly assigned to groups using a digital table with numbers ranging from 0 to 80.Children with odd numbers were treated with montelukast sodium tablets(40 cases,control group),while those with even numbers were treated with montelukast sodium tablets and Xiaoer Kechuan Granules(40 cases,observation group).Meanwhile,both groups were given conventional treatment regimens.Comparison was made on time required for symptom improvement,inflammatory factor levels,incidence of adverse reactions,lung function indicators,and immune function levels between the two groups.Results The time to resolution of wheezing in the observation group was(2.75±0.21)d,the time to resolution of coughing was(2.86±0.18)d,the time to resolution of expectoration was(1.68±0.25)d,and the time to resolution of asthma was(1.85±0.25)d,which were shorter than those in the control group[(5.25±0.21),(4.65±0.12),(3.68±0.35),and(3.38±0.19)d](P<0.05).After treatment,the levels of C-reactive protein,serum tumor necrosis factor-α,interleukin-8 and interleukin-10 in the observation group were all lower than those in the control group(P<0.05).The incidence of adverse reactions 7.50%in the observation group was lower than 25.00%in the control group(P<0.05).After treatment,the peak expiratory flow rate,forced vital capacity,and forced expiratory volume in one second/forced vital capacity in the observation group were higher than those in the control group(P<0.05).After treatment,the improvement of NK cells,CD4^(+)and CD8^(+)levels in the observation group was more significant compared with those in the control group(P<0.05).Conclusion The application of Xiaoer Kechuan Granules for the treatment of children with acute bronchitis can promote rapid improvement of symptoms,reduce levels of inflammatory factors,improve pulmonary function,and reduce adverse reactions.
作者
双艳艳
马红霞
SHUANG Yan-yan;MA Hong-xia(Department of Pediatrics,Jingbian County People's Hospital,Yulin 718500,China)
出处
《中国实用医药》
2025年第20期15-18,共4页
China Practical Medicine
关键词
小儿咳喘颗粒
小儿急性支气管炎
肺功能
不良反应
Xiaoer Kechuan Granules
Acute bronchitis in children
Pulmonary function
Adverse reactions
