摘要
肺癌是目前全球发病率和死亡率最高的恶性肿瘤。近年来,随着肿瘤治疗技术的不断发展,肺癌患者的生存期得到延长,高龄患者在肺癌患者中的比例相应升高。高龄肺癌患者并发心血管疾病的比例更高,且在抗肿瘤过程中新发心血管疾病的风险也更高,而肺癌患者一旦合并心血管疾病,将极大地影响抗肿瘤治疗的疗效,并且心血管疾病相关死亡也是肿瘤非特异性死亡的重要原因。该综述旨在通过总结肺癌与心血管疾病的共同危险因素,不同抗肿瘤治疗诱发心血管事件的相关机制及防治策略和肿瘤治疗相关心血管事件预测指标,为肺癌患者抗肿瘤治疗过程中早期识别并防治心血管事件、改善预后,提高生存质量提供理论依据。
Lung cancer currently ranks as the malignant neoplasm with the highest global incidence and mortality rates.In recent years,with the continuous advancement of cancer treatment technologies,the survival period of lung cancer patients has been extended to a certain degree,consequently increasing the proportion of elderly patients among those with lung cancer.Elderly lung cancer patients have a higher prevalence of comorbid cardiovascular diseases and face an elevated risk of developing new cardiovascular conditions during antineoplastic treatment.The coexistence of cardiovascular diseases in lung cancer patients significantly impacts the efficacy of anticancer therapy,and cardiovascular-related mortality represents a major cause of non-cancer-specific death.This review aims to summarize the shared risk factors between lung cancer and cardiovascular diseases,the mechanisms underlying cardiovascular events induced by various antineoplastic treatments,prevention and management strategies,and predictive indicators of cancer therapy-related cardiovascular events.The objective is to provide a theoretical basis for early identification and prevention of cardiovascular events in the clinical treatment of lung cancer patients,thereby improving prognosis and enhancing quality of life.
作者
薛天宇
张新玲
李长宁
张浩
徐静雯
王楠
XUE Tianyu;ZHANG Xinling;LI Changning;ZHANG Hao;XU Jingwen;WANG Nan(Jining Medical University,Shandong Jining 272067,China;Department of Cardiology,the First Affiliated Hospital of Shandong First Medical University,Shandong Jinan 250014,China;Department of Gastroenterology,Affiliated Hospital of Jining Medical University,Shandong Jining 272000,China;Department of Nephrology,Affiliated Hospital of Jining Medical University,Shandong Jining 272000,China;The First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Shandong Jinan 250014,China;Department of Minimally Invasive Oncology,the First Affiliated Hospital of Shandong First Medical University,Shandong Jinan 250014,China)
出处
《现代肿瘤医学》
2025年第10期1808-1815,共8页
Journal of Modern Oncology
基金
国家自然科学基金(编号:82205061)
国家重点研发计划“发育编程及其代谢调节”重点专项(编号:2023YFA1800900)
山东省自然科学基金青年项目(编号:ZR2024QH100)
山东省山东大学科技计划项目(编号:202225074)。
关键词
肿瘤心脏病学
心血管事件
肺癌
癌症治疗
预测因子
cardio-oncology
cardiovascular event
lung cancer
cancer treatment
predictive factor
