摘要
目的分析基线神经元特异性烯醇化酶(NSE)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)及其变化值预测丁苯酞辅助治疗急性脑梗死患者预后的价值。方法选取2021年1月至2024年1月宿州市中医医院脑病科150例急性脑梗死患者,按治疗方法分为观察组80例和对照组70例。对照组接受基础治疗,观察组在此基础上加用丁苯酞,两组均治疗14天。对比两组治疗前后NSE、hs-CRP、IL-6指标。将观察组患者随访3个月的预后分为良好组和不良组,通过单因素和多因素logistic回归分析影响丁苯酞辅助治疗预后的相关因素,利用ROC曲线分析NSE、hs-CRP、IL-6及指标变化量(^(△)NSE、^(△)hs-CRP、^(△)IL-6)对预后的预测价值。结果两组治疗后NSE、hs-CRP、IL-6水平均下降,且观察组低于对照组(P<0.05)。单因素分析表明,NSE、hs-CRP、IL-6、^(△)NSE、^(△)hs-CRP、^(△)IL-6及高血压是预后不良危险因素(P<0.05);多因素logistic回归显示,NSE、hs-CRP、IL-6、^(△)NSE、^(△)hs-CRP、^(△)IL-6为独立危险因素(P<0.05)。ROC分析中,NSE、hs-CRP、IL-6、^(△)NSE、^(△)hs-CRP、^(△)IL-6及联合检测的AUC分别为0.754、0.833、0.746、0.736、0.904、0.733和0.965(P<0.05)。结论丁苯酞辅助治疗可改善急性脑梗死患者的NSE、hs-CRP、IL-6,且基线NSE、hs-CRP、IL-6及其变化值对丁苯酞辅助治疗急性脑梗死患者预后具有较高的预测价值。
Objective To analyze the value of neuron⁃specific enolase(NSE),high⁃sensitivity C⁃reactive protein(hs⁃CRP),interleukin⁃6(IL⁃6)and their changes in predicting the prognosis of patients with acute cerebral infarction treated with butylphthalide.Methods A total of 150 patients with acute cerebral infarc⁃tion were selected from the Department of Encephalopathy at Suzhou Hospital of Traditional Chinese Medicine from January 2021 to January 2024.They were divided into an observation group(80 cases)and a control group(70 cases)based on the treatment methods.The control group received basic treatment,while the observation group received butylphthalide in addition to basic treatment.Both groups underwent a 14⁃day treatment regimen.The levels of NSE,hs⁃CRP,and IL⁃6 were compared between the two groups before and after treatment.After 3 months of follow⁃up,patients in the observation group were further categorized into a good group and a poor group.Univariate and multivariate logistic regression analyses were conducted to identify factors influencing the prognosis of butylphthalide adjuvant therapy.ROC curve analysis was used to assess the predictive value of NSE,hs⁃CRP,IL⁃6,and their changes(^(△)NSE,^(△)hs⁃CRP,^(△)IL⁃6)for prognosis.Results After treatment,the levels of NSE,hs⁃CRP,and IL⁃6 in the two groups decreased,with those in the observation group being lower than those in the control group(P<0.05).Univariate analysis showed that NSE,hs⁃CRP,IL⁃6,^(△)NSE,^(△)hs⁃CRP,^(△)IL⁃6,and hypertension were risk factors for poor prognosis(P<0.05).Multivariate logistic regression analysis revealed that NSE,hs⁃CRP,IL⁃6,^(△)NSE,^(△)hs⁃CRP,and^(△)IL⁃6 were independent risk factors(P<0.05).ROC analysis demonstrated that the AUC of NSE,hs⁃CRP,IL⁃6,^(△)NSE,^(△)hs⁃CRP,^(△)IL⁃6,and combined detection were 0.754,0.833,0.746,0.736,0.904,0.733 and 0.965,respectively(P<0.05).Conclusion Butylphthalide adjuvant therapy can improve levels of NSE,hs⁃CRP,and IL⁃6 in patients with acute cerebral infarction.The base⁃line levels of NSE,hs⁃CRP,IL⁃6,as well as their changes,have a high predictive value for the prognosis of pa⁃tients with acute cerebral infarction.
作者
尹春梅
邵子杰
刘石雷
徐会会
桑田田
万宁
张瑞发
YIN Chunmei;SHAO Zijie;LIU Shilei;XU Huihui;SANG Tiantian;WAN Ning;ZHANG Ruifa(Department of Encephalopathy,Suzhou Hospital of Traditional Chinese Medicine,Suzhou,Anhui,China,234000)
出处
《分子诊断与治疗杂志》
2025年第8期1457-1460,共4页
Journal of Molecular Diagnostics and Therapy
基金
安徽省卫生健康委科研项目(AHWJ2021b044)。
关键词
神经元特异性烯醇化酶
超敏C反应蛋白
白细胞介素-6
丁苯酞
急性脑梗死
Neuron specificity enolization enzyme
High⁃sensitivity C⁃reactive protein
Interleukin⁃6
Butylphthalide
Acute progressive cerebral infarction
