摘要
微小RNA(miRNA)作为一类内源性非编码单链RNA,长度约为21~25个核苷酸,以自分泌、旁分泌或远距离分泌的方式作用,在转录后水平调控基因的表达,参与心肌肥厚、心肌细胞凋亡、心肌纤维化、离子通道变化、心肌能量代谢紊乱等心衰的多种病理进程。现就miRNA在心力衰竭中的作用进行综述。
As a class of endogenous non⁃coding single⁃stranded RNAs,with a length of about 21⁃25 nucleotides,microRNAs(miRNAs)act in an autocrine,paracrine,or teleocrine manner,regulating gene expression at the post⁃transcriptional level and participating in a variety of pathological processes of heart failure,such as myocardial hypertrophy,apoptosis of cardiomyocytes,myocardial fibrosis,changes in ion channels,and disturbances in myocardial energy metabolism.The role of miRNAs in heart failure is now reviewed.
作者
江琼瑶
刘德华
钱净
JIANG Qiongyao;LIU Dehua;QIAN Jing(Department of Laboratory Medicine,The First People's Hospital of Kunming,Kunming,Yunnan,China,650011)
出处
《分子诊断与治疗杂志》
2025年第8期1385-1387,1395,共4页
Journal of Molecular Diagnostics and Therapy
基金
昆明医科大学研究生教育创新基金(2023S394)
昆明市科技局春城计划高层次创新创业团队专项(5G+分子)(2022SCP002-C-3)。
