摘要
目的:观察自拟养阴清肺汤离子导入与传统敷贴治疗小儿慢性咳嗽的临床疗效及对肺功能、血清免疫球蛋白E(IgE)、免疫球蛋白A(IgA)水平的影响。方法:纳入2022年5月—2023年10月在淳安县妇幼保健院治疗的80例慢性咳嗽患儿,按随机数字表法分为研究组和对照组各40例。对照组采用养阴清肺汤传统敷贴治疗,研究组采用养阴清肺汤离子导入治疗。疗程均为14天,比较2组临床疗效、临床症状缓解时间、肺功能指标[第1秒用力呼气量(FEV_(1))、最大呼吸流量(PEF)、用力肺活量(FVC)、呼吸频率(RR)]以及血清IgE、IgA因子水平。结果:治疗后,研究组总有效率为95.00%(38/40),对照组为77.50%(31/40),2组比较,差异有统计学意义(P<0.05)。治疗后,研究组咳嗽减轻时间、肺部啰音消失时间、呼吸音清晰时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,2组FEV_(1)、PEF、FVC水平均较治疗前升高(P<0.05),RR水平均较治疗前降低(P<0.05);且研究组FEV_(1)、PEF、FVC水平均高于对照组(P<0.05),RR水平低于对照组(P<0.05)。治疗后,2组IgE水平均较治疗前降低(P<0.05),IgA水平较治疗前升高(P<0.05);且研究组IgE水平低于对照组(P<0.05),IgA水平高于对照组(P<0.05)。结论:养阴清肺汤离子导入与传统敷贴治疗小儿慢性咳嗽疗效确切,能够有效缓解临床症状,改善患儿肺功能及免疫功能,且离子导入给药疗效优于传统敷贴。
Objective:To observe the clinical effect of self-formulated Yangyin Qingfei Decoction delivered by iontophoresis and traditional point application on chronic cough in children,and their effects on lung function and levels of immunoglobulin E(IgE)and immunoglobulin A(IgA)in serum.Methods:A total of 80 cases of children with chronic cough treated at Chun'an County Maternal and Child Health Hospital from May 2022 to October 2023 were included and divided into the study group and the control group according to the random number table method,with 40 cases in each group.The control group received traditional point application with Yangyin Qingfei Decoction,and the study group received iontophoresis with Yangyin Qingfei Decoction.The treatment course was 14 days for both groups.Clinical effects,time to symptom relief,lung function indicators[forced expiratory volume in the first second(FEV_(1)),peak expiratory flow(PEF),forced vital capacity(FVC),respiratory rate(RR)],and levels of IgE and IgA in serum were compared between the two groups.Results:After treatment,the total effective rate was 95.00%(38/40)in the study group and 77.50%(31/40)in the control group,with a significant difference between the two groups(P<0.05).The study group showed shorter time to cough reduction,disappearance of lung rales,and clear breath sounds compared to the control group,with significant differences(P<0.05).After treatment,both groups showed increased levels of FEV_(1),PEF,and FVC compared to before treatment(P<0.05),and decreased RR levels(P<0.05);the study group had higher levels of FEV_(1),PEF,and FVC than the control group(P<0.05)and lower RR level than the control group(P<0.05).After treatment,both groups showed decreased IgE levels and increased IgA levels compared to before treatment(P<0.05);the study group had lower IgE level than the control group(P<0.05)and higher IgA level than the control group(P<0.05).Conclusion:Yangyin Qingfei Decoction delivered by iontophoresis and traditional point application have a definite curative effect in treating chronic cough in children.It can significantly alleviate clinical symptoms and improve lung function and immune function,with iontophoresis being superior to traditional point application.
作者
程骏
莫晓东
邓鸣霞
CHENG Jun;MO Xiaodong;DENG Mingxia(Department of Pediatrics,Chun'an County Maternal and Child Health Hospital,Chun'an Zhejiang 311700,China;Department of Pediatrics,Linping Branch of Hangzhou Hospital of Traditional Chinese Medicine,Hangzhou Zhejiang 311106,China)
出处
《新中医》
2025年第14期30-34,共5页
New Chinese Medicine
关键词
小儿慢性咳嗽
养阴清肺汤
离子导入
肺功能
免疫球蛋白
Chronic cough in children
Yangyin Qingfei Decoction
Iontophoresis
Lung function
Immunoglobulin
