摘要
目的探讨康复新液辅助四联疗法治疗幽门螺杆菌(Hp)阳性十二指肠球后溃疡(PBDU)患者的临床效果。方法选取我院收治的140例Hp阳性PBDU患者,采用随机数字表法将其分为对照组与观察组,每组70例。对照组给予传统四联疗法,观察组在对照组基础上加用康复新液治疗。比较两组的治疗效果。结果观察组的治疗总有效率及Hp根除率高于对照组(P<0.05)。治疗1、7、14 d后,观察组的视觉模拟评分法(VAS)评分低于对照组(P<0.05)。治疗后,观察组的丙二醛(MDA)水平低于对照组,谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)及转化生长因子-α(TGF-α)水平高于对照组(P<0.05)。治疗后,观察组的C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、核因子-κB(NF-κB)以及高迁移率族蛋白B1(HMGB1)水平低于对照组(P<0.05)。治疗后,观察组的CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD8^(+)低于对照组(P<0.05)。结论康复新液辅助四联疗法治疗Hp阳性PBDU患者的临床效果显著。
Objective To investigate the clinical effect of Kangfuxin liquid assisted quadruple therapy in the treatment of patients with Helicobacter pylori(Hp)positive post-bulbar duodenal ulce(PBDU).Methods A total of 140 patients with Hp-positive PBDU admitted in our hospital were selected and divided into control group and observation group by random number table method,with 70 cases in each group.The control group was given traditional quadruple therapy,and the observation group was treated with Kangfuxin liquid on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment and Hp eradication rate in the observation group were higher than those in the control group(P<0.05).After 1,7 and 14 d of treatment,the Visual Analogue Scale(VAS)score of the observation group was lower than that of the control group(P<0.05).After treatment,the level of malondialdehyde(MDA)in the observation group was lower than that in the control group,and the levels of glutathione peroxidase(GSH-Px),superoxide dismutase(SOD)and transforming growth factor-α(TGF-α)were higher than those in the control group(P<0.05).After treatment,the levels of C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),nuclear factor-κB(NF-κB)and high mobility group box-1 protein(HMGB1)in the observation group were lower than those in the control group(P<0.05).After treatment,CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,and CD8^(+)was lower than that in the control group(P<0.05).Conclusion The Kangfuxin liquid assisted quadruple therapy in the treatment of Hp positive PBDU patients has significant clinical effect.
作者
周将
赵亮
宁爱丽
肖业
赵姝姗
ZHOU Jiang;ZHAO Liang;NING Aili;XIAO Ye;ZHAO Shushan(Geriatrics Medicine Department,Yiyang Central Hospital Affiliated to Hunan University of Chinese Medicine,Yiyang 413000,China)
出处
《临床医学研究与实践》
2025年第25期74-77,共4页
Clinical Research and Practice
关键词
十二指肠球后溃疡
幽门螺杆菌
康复新液
四联疗法
post-bulbar duodenal ulce
Helicobacter pylori
Kangfuxin liquid
quadruple therapy
