摘要
旨在系统评估饲粮中添加植物精油(essential oils,EOs)对哺乳期犊牛血清免疫及生化指标的影响。通过荟萃分析(Meta分析)方法,对截至2024年4月已发表的537篇文献进行筛选,最终纳入17篇文献,涉及样本711例。采用随机效应模型(REM)计算合并统计量,并进行亚组分析、敏感性分析和发表偏倚分析。Meta分析结果显示:饲粮中添加EOs极显著提高了哺乳期犊牛血清中免疫球蛋白A(IgA)[标准化均数差(SMD)=0.66,95%置信区间(95%CI):0.23~1.08,P<0.002]、免疫球蛋白G(IgG)(SMD=0.70,95%CI:0.37~1.02,P<0.001)以及甘油三酯(TG)的浓度(SMD=0.51,95%CI:0.10~0.92,P=0.01);显著提高了血清中免疫球蛋白M(IgM)(SMD=0.49,95%CI:0.03~0.96,P=0.04)和总蛋白(TP)的浓度(SMD=0.45,95%CI:0.03~0.87,P=0.04),并显著降低了总胆固醇(TC)浓度(SMD=-0.59,95%CI:-1.07~-0.11,P=0.02)。亚组分析通过结合有效性与稳定性比较表明,短期饲喂(≤56 d)EOs的效果优于长期饲喂(>56 d);通过固体饲料添加EOs的效果优于通过液体饲料添加。敏感性分析和发表偏倚分析表明,研究结果具有稳定性和可靠性。综上所述,本研究采用Meta分析方法为EOs在犊牛生产中的应用奠定了理论基础,表明在饲粮中添加EOs可以有效改善哺乳期犊牛的血清免疫及生化指标。
This study aims to systematically evaluate the effects of adding essential oils(EOs)to the diet on serum immune and biochemical indicators in suckling calves.A Meta-analysis was conducted by screening 537 published studies up until April 2024,with 17 studies involving and a total of 711 samples being included.A random effects model(REM)was used to calculate combined statistical measures,and subgroup analysis,sensitivity analysis,and publication bias analysis were also performed.The Meta-analysis results showed that adding EOs to the diet significantly increased the concentrations of immunoglobulin A(IgA)(SMD=0.66,95%CI:0.23-1.08,P<0.002),immunoglobulin G(IgG)(SMD=0.70,95%CI:0.37-1.02,P<0.001),and triglycerides(TG)(SMD=0.51,95%CI:0.10-0.92,P=0.01)in the serum of suckling calves.EOs also significantly increased the concentrations of immunoglobulin M(IgM)(SMD=0.49,95%CI:0.03-0.96,P=0.04)and total protein(TP)(SMD=0.45,95%CI:0.03-0.87,P=0.04),and significantly reduced the concentration of total cholesterol(TC)(SMD=-0.59,95%CI:-1.07 to-0.11,P=0.02).Subgroup analysis,comparing effectiveness and stability,indicated that short-term feeding(≤56 days)of EOs is more effective than long-term feeding(>56 days),and adding EOs via solid feed(SF)is more effective than via liquid feed(LF).Sensitivity analysis and publication bias analysis confirmed the stability and reliability of the results.In conclusion,this study establishes a theoretical foundation for the application of EOs in calf production through Meta-analysis,demonstrating that adding EOs to the diet can effectively improve serum immune and biochemical indicators in suckling calves.
作者
王琳玮
王靖
韩赛波
李涵川
王盼盼
郭刚
蒋林树
WANG Linwei;WANG Jing;HAN Saibo;LI Hanchuan;WANG Panpan;GUO Gang;JIANG Linshu(Beijing Key Laboratory of Dairy Cow Nutrition,Beijing University of Agriculture,Beijing 102206,China;Beijing Sunlon Livestock Development Co.,Ltd.,Beijing 100176,China)
出处
《畜牧兽医学报》
北大核心
2025年第8期3872-3892,共21页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
家禽产业技术体系北京市创新团队(BAICO5)
乳业全产业链“绿色数智”技术集成创新与产业化应用[SNSPKJ(2022)]。
关键词
犊牛
植物精油
META分析
血清免疫指标
血清生化指标
calves
essential oils
Meta-analysis
serum immune indicators
serum biochemical indicators
