摘要
小檗碱是一种异喹啉类生物碱,广泛存在于黄连、黄柏等植物中,具有多种药理活性,在代谢性疾病、感染性疾病及炎症等领域具有较好的临床应用效果。近年来,小檗碱的抗肿瘤作用也备受关注。研究表明,小檗碱可通过多途径抑制肿瘤进展,如诱导肿瘤细胞凋亡,调控肿瘤内微生物组,阻滞细胞周期,抑制肿瘤毛细血管生成以及增强肿瘤免疫效果等。此外,小檗碱能通过调节磷脂酰肌醇3激酶/蛋白激酶B、丝裂原活化蛋白激酶、核因子κB等关键信号通路,协同增强化疗药物敏感性并减轻耐药性。小檗碱的抗氧化与免疫调节功能进一步拓展了抗肿瘤应用潜力。该文基于小檗碱的基础和临床研究成果,综述了小檗碱的抗肿瘤作用机制及临床应用进展,同时讨论了小檗碱抗肿瘤临床转化方面的挑战及潜在的解决策略,为其开发为新型抗肿瘤药物提供参考。
Berberine,an isoquinoline alkaloid,is abundant in plants such as Coptis and Phellodendri.It exhibits a wide range of pharmacological activities and has been effectively applied in the clinical treatment of metabolic diseases,infectious diseases,and inflammation.In recent years,berberine's anti-tumor effects have garnered significant attention.Research has demonstrated that berberine can inhibit tumor progression via multiple pathways,including inducing tumor cell apoptosis,regulating the tumor microbiome,arresting the cell cycle,inhibiting tumor angiogenesis,and enhancing the efficacy of tumor immunotherapy.Additionally,berberine can synergistically increase the sensitivity of chemotherapeutic drugs and reduce drug resistance by modulating key signaling pathways such as PI3K/Akt,MAPK,and NF-κB.The antioxidant and immunomodulatory properties of berberine further expand its potential for anti-tumor applications.Based on the findings from basic and clinical research,this review systematically summarizes the latest advances in berberine's anti-tumor mechanisms and clinical applications.It also discusses the challenges and potential solutions in the clinical translation of berberine for cancer therapy,providing a theoretical basis for its development as a novel anti-tumor drug.
作者
周良春
吕佳昕
王冬园
ZHOU Liangchun;LYU Jiaxin;WANG Dongyuan(Department of Pharmacy,Huanggang Central Hospital,Huanggang 438000,China;School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Pharmacy,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)
出处
《医药导报》
北大核心
2025年第8期1229-1235,共7页
Herald of Medicine
关键词
小檗碱
肿瘤细胞凋亡
肿瘤免疫治疗
调节自噬
肿瘤代谢
表观遗传学
Berberine
Tumor cell apoptosis
Tumor cell immunotherapy
Autophagy regulation
Tumor metabolism
Epigenetics
