摘要
Atherosclerosis(AS)is a long-term vascular disorder primarily initiated by the combined effects of lipid deposition,endothelial injury,and inflammatory responses.It can even lead to death and represent a significant threat to human health and well-being.Lipophagy,a form of selective autophagy discovered recently,is defined as degrading lipid droplets through autophagic pathways to eliminate excess lipids.Studies have shown that lipophagy is critical in several key pathological processes of AS,including inflammation,oxidative stress damage,and foam cell formation.It is also closely associated with the instability of lipid plaques.This paper aims to provide an overview of recent domestic and international research on the characteristic mechanisms of lipophagy in the formation and progression of AS.It also summarizes the role of traditional Chinese medicine in regulating lipophagy to intervene in the progression of AS.The objective is to enhance the understanding of lipophagy and promote greater attention to the use of traditional Chinese medicine in preventing and managing AS.
基金
supported by the National Nature Science Foundation of China(82374367)
Jiangxi Provincial Natural Science Foundation(20242BAB26163,20232BAB206144)
NATCM’s Project of High-level Construction of Key TCM Disciplines(zyyzdxk-2023113)
Project of Key Discipline Construction Fund of Jiangxi University of Chinese Medicine(2023jzzdxk032)
Science and Technology Innovation Team Development Program of Jiangxi University of Chinese Medicine(CXTD22011)
Graduate Innovation Special Fund of Jiangxi University of Chinese Medicine(XJ-S202452).
