摘要
Cerebral small vessel disease(CSVD),a chronic and progressive vascular disorder closely associated with stroke and dementia,is primarily identified and diagnosed in cranial magnetic resonance imaging(MRI).Given the limited evidence on the relationship between air pollution and CSVD,this study aimed to investigate the links between multiple air pollutants exposure and CSVD risk.Eligible subjects and their cranial MRI data were obtained from the Multi-modality Medical Imaging Study Based on Kailuan Study,totaling 1216 participants.Ordinal and binary logistic regression models were utilized to evaluate the associations between air pollution exposure and the neuroimaging markers of CSVD.For each interquartile range increase in air pollutant exposure during the examination year,the odds ratios and 95% confidence intervals of the increased white matter hyperintensity burden were 1.45(1.15,1.84)for PM_(2.5),1.72(1.27,2.34)for PM_(10),1.26(1.05,1.51)for SO_(2),1.52(1.16,2.00)for NO_(2),and 1.63(1.26,2.13)for CO.The results remained consistent even when the model was fitted using air pollution from different exposure windows.Furthermore,the estimated effect sizes for the total burden of CSVD were 1.20(1.01,1.43)for PM_(2.5),1.39(1.12,1.74)for PM_(10),1.26(1.03,1.53)for NO_(2),and 1.30(1.08,1.58)for CO.These findings suggest that a positive link between air pollutants exposure and neuroimaging markers of CSVD in the Chinese population,revealing the importance of controlling environmental pollutants to protect the population against cerebral small vessel damage.
基金
supported by the National Natural Science Foundation of China(grant 82304231)
Natural Science Foundation of Hubei Province(grant 2022CFB621).
