摘要
心肌梗死(myocardial infarction, MI)是众多心血管疾病中最常见且最危险的一种。MI后炎症反应的加重、延长或扩大会导致更严重的重塑和功能障碍。心肌纤维化是MI后终末期不可避免的病理过程,常导致严重的心功能不全甚至死亡,是MI患者导致心力衰竭致死的主要原因。MI后心脏经历了以心肌纤维化为主要病理生理进程的连续性改变。纤维化是心肌梗死修复过程中的一个重要环节,在MI早期,梗死区域的修复性纤维化帮助心脏维持其结构的完整性,防止心室壁破裂;在MI后期,过度的纤维化会使心肌组织变得僵硬,导致心室重构,影响心脏的收缩和舒张功能。消退素(resolvin D1,RvD1)是一种由二十二碳六烯酸转化而来的一种新型促炎性消退脂质递质,在许多临床前疾病模型中通过抑制炎症反应和促进组织修复来减轻疾病症状并延缓疾病进程,进而发挥其抗炎和抗氧化等作用。研究表明,RvD1已被用于通过限制炎症诱导心脏保护,表明RvD1在心血管疾病中同样也发挥着重要作用。然而,其在心肌梗死后心肌纤维化(cardiac fibrosis after myocardial infraction, CFMI)过程中的作用和机制尚不清楚。本综述旨在总结和分析RvD1的结构、生物学效应及其在CFMI中的作用机制及研究进展。
Myocardial infarction (MI) is one of the most common and life-threatening cardiovascular diseases. The exacerbation, persistence, or expansion of the inflammatory response after MI leads to more severe remodeling and dysfunction. Myocardial fibrosis is an unavoidable pathological process in the late phase following MI, often leading to severe cardiac insufficiency or even death, and is a major cause of heart failure-related mortality in MI patients. The heart undergoes a continuum of pathological changes after MI, among which myocardial fibrosis is the main predominant process. Fibrosis plays a critical role in the myocardial repair process. In the early stage of MI, reparative fibrosis in the infarcted area helps maintain structural integrity and prevents ventricular wall rupture. In contrast, in the chronic phase, excessive fibrosis increases myocardial stiffness, leading to adverse ventricular remodeling and impairing both systolic and diastolic functions. Resolvin D1 (RvD1), a novel pro-resolving lipid mediator derived from docosahexaenoic acid, reduces disease symptoms and delays disease progression by inhibiting inflammatory responses and promoting tissue repair in multiple preclinical models, exerting anti-inflammatory, antioxidant effects, and other protective effects. Recent studies have shown that RvD1 confers cardioprotective effects by limiting inflammation, suggesting its potential therapeutic value in cardiovascular diseases. However, the specific role and underlying mechanism of RvD1 cardiac fibrosis after myocardial infraction (CFMI) are still unclear. The aim of this review is to summarize and analyze the structure, biological function, mechanism of action of RvD1, and the current research progress on its role in CFMI.
作者
郝智博
刘燕
黄照河
HAO Zhibo;LIU Yan;HUANG Zhaohe(Graduate School of Youjiang Medical University for Nationalities,Baise,Guangxi,533000,China;Affiliated Hospital of Youjiang Medical University for Nationalities)
出处
《临床心血管病杂志》
2025年第7期527-534,共8页
Journal of Clinical Cardiology
基金
国家自然科学基金项目(No:82260883)。
关键词
消退素D1
心肌梗死
心肌纤维化
resolvin D1
myocardial infarction
myocardial fibrosis
