摘要
中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)是由组蛋白和中性粒细胞颗粒蛋白组成的DNA网状结构,在中性粒细胞捕获和杀死病原体过程中起重要作用。在心肌梗死过程中,中性粒细胞激活导致NETs水平的异常升高,加重了炎症反应和组织损伤。目前研究提示,相关离子通道的活化可通过不同途径调控NETs形成,导致心肌梗死后损伤加重、心律失常等心血管不良事件的发生。本文阐述了NETs的形成途径和对急性心肌梗死的作用,并详细描述了中性粒细胞上小电导钙激活钾通道、瞬时感受器电位离子通道、P2X受体和囊性纤维化跨膜电导调节体等在NETs形成中的作用和机制,为减轻心肌梗死后心脏重塑和心律失常提供新的思路。
Neutrophil extracellular traps(NETs)are web-like DNA structures decorated with histones and neutrophil granule proteins in capturing and killing pathogens.During myocardial infarction,an abnormal increase in the level of NETs exacerbates the inflammatory response and tissue damage.The current study suggests that activation of related ion channels may regulate the formation of NETs through different pathways,leading to cardiovascular adverse events such as ventricular remodeling and arrhythmias after myocardial infarction.In this paper,we first described the pathways during NETs formation and their role in acute myocardial infarction.We also summarized in detail the role and mechanism of ion channels in NETs formation during acute myocardial infarction,including SK,TRP,P2X,and CFTR on neutrophils,which may provide new ideas for mitigating cardiac remodeling and arrhythmias after myocardial infarction.
作者
吴雨薇
吴琼峰
杜以梅
WU Yuwei;WU Qiongfeng;DU Yimei(Department of Cardiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China;Hubei Key Laboratory of Biological Targeted Therapy;Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases;Department of Cardiology,Wuhan Third Hospital)
出处
《临床心血管病杂志》
CAS
2024年第5期358-365,共8页
Journal of Clinical Cardiology
基金
国家自然科学基金项目(No:81900324、82170326)
关键词
中性粒细胞胞外诱捕网
离子通道
活性氧
neutrophil extracellular traps
ion channels
reactive oxygen species
