摘要
目的分析儿童B细胞急性淋巴细胞白血病(B-ALL)复发的危险因素。方法收集了2021年1月至2023年3月期间在医院就诊的81名患有B-ALL的患者纳入研究,为复发组(21人)和未复发组(60人)。比较两组的基本临床特点和白血病病例特点。使用Logistic回归分析B-ALL复发的相关因素。结果在21例复发B-ALL病例中,18例(85.71%)为单纯骨髓复发,2例(9.52%)为中枢神经系统复发,1例(4.76%)为睾丸复发。两组的年龄,化疗引起的白细胞减少时间(天)、新诊断时外周血白细胞计数、33天的最小残留病(MRD)和12周的MRD具有显著差异。因素Logistic回归分析结果发现年龄≥10岁(调整后OR=2.54,95%CI 1.14~5.23,P=0.002)、12周的MRD>10^(-4)(调整后OR=2.34,95%CI 1.53~5.21,P=0.001)为B-ALL患者复发的独立危险因素。结论儿童年龄≥10岁和12周的MRD>10^(-4)为B-ALL患者复发的独立危险因素。
Objective To analyze the risk factors for relapse of B-cell acute lymphoblastic leukemia(B-ALL)in children.Methods Eighty-one patients with B-ALL who attended the hospital between January 2021 and March 2023 were collected for inclusion in the study,as the relapsed group(21)and the non-relapsed group(60).Basic clinical characteristics and leukemia case characteristics were compared between the two groups.Factors associated with B-ALL relapse were analyzed using logistic regression.Results Of the 21 relapsed B-ALL cases,18(85.71%)were pure bone marrow relapses,2(9.52%)were central nervous system relapses,and 1(4.76%)was a testicular relapse.Age,duration of chemotherapy-induced leukopenia decreased(days),peripheral blood leukocyte count at new diagnosis,minimal residual disease(MRD)at 33 days and MRD at 12 weeks were significantly different between the two groups.Factor logistic regression analysis revealed that age≥10 years(adjusted OR=2.54,95%CI 1.14~5.23,P=0.002)and MRD>10^(-4) at 12 weeks(adjusted OR=2.34,95%CI 1.53~5.21,P=0.001)were found to be recurrence in patients with B-ALL independent risk factor for recurrence.Conclusion MRD>10^(-4) in children aged≥10 years and 12 weeks were independent risk factors for relapse in B-ALL patients.
作者
杨晓亭
黄彩娟
邱少佳
YANG Xiao-ting;HUANG Cai-juan;QIU Shao-jia(Department of Hematopathology,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan Province,China)
出处
《罕少疾病杂志》
2025年第8期140-142,共3页
Journal of Rare and Uncommon Diseases
关键词
急性淋巴细胞白血病
儿童
复发
危险因素
最小残留病
Acute Lymphoblastic Leukemia
Children
Relapse
Risk Factors
Minimal Residual Disease
