摘要
脓毒症是感染引发的全身炎症反应,常导致多器官功能衰竭,其中肺损伤是早期且严重的并发症,临床治疗手段有限。丹参酮ⅡA是由丹参中提取的二萜醌类化合物,可通过减轻炎症反应,降低氧化应激反应,维持肺微血管屏障功能,纠正炎症与凝血失衡,增强细胞自噬减轻脓毒症引起的肺损伤。总结了丹参酮ⅡA防治脓毒症肺损伤的药理作用研究进展,为脓毒症肺损伤的临床治疗提供参考。
Sepsis is a systemic inflammatory response caused by infection,which often leads to multiple organ failure.Among them,lung injury is an early and serious complication,and clinical treatment methods are limited.Tanshinone IIa is a diterpenoid quinone compound from Salviae Miltiorrhizae Radix et Rhizoma.Tanshinone A can alleviate sepsis induced lung injury by reducing inflammatory response,lowering oxidative stress response,maintaining pulmonary microvascular barrier function,correcting inflammation and coagulation imbalance,enhancing cellular autophagy.This article summarizes the pharmacological research progress of tanshinone IIA in preventing and treating sepsis induced lung injury,providing reference for the clinical treatment of sepsis induced lung injury.
作者
戚雯杰
黄明斌
苏舒
于洋
闫东来
于泳浩
QI Wenjie;HUANG Mingbin;SU Shu;YU Yang;YAN Donglai;YU Yonghao(Department of Anesthesiology,Tianjin Huanghe Hospital,Tianjin 300110,China;Department of Pain,Tianjin Huanghe Hospital,Tianjin 300110,China;Department of Anesthesiology,Tianjin Medical University General Hospital,Tianjin 300041,China)
出处
《现代药物与临床》
2025年第7期1868-1872,共5页
Drugs & Clinic
关键词
丹参酮ⅡA
脓毒症肺损伤
炎症反应
氧化应激反应
肺微血管屏障功能
凝血失衡
细胞自噬
tanshinone IIa
septicemia induced lung injury
inflammatory response
oxidative stress response
pulmonary microvascular barrier function
coagulation imbalance
cellular autophagy
