摘要
目的:系统评价相位角(PA)检测癌症患者营养不良状态的敏感性,总结PA在不同癌症人群中的临界值特点及影响因素。方法:利用关键词检索中国知网(CNKI)、万方数据知识服务平台、维普网、PubMed、Web of Science、Cochrane Library、Embase中公开发表的关于PA应用于癌症患者营养不良检测方面的临床研究,检索时限为建库至2024年7月,对筛选出的临床对照试验进行数据提取,总结PA值在临床上的最新研究及应用情况,探索不同癌症患者群的PA临界值特点及影响因素并作出综合评价。结果:共纳入19项相关研究,共3280名受试者不同时期患不同类型癌症。所选文献整体质量较高,4篇研究明确界定了营养状况不良的PA临界值,5篇研究指出影响PA值的独立性因素及低PA值的相关并发症,6篇研究明确指出PA值与生存率之间的关联,6篇研究将PA结合其他指标来预测营养不良风险。结果显示PA作为评价营养状态的客观指标,可以用于评估细胞膜状态及人体营养状况,与癌症生存率之间呈正相关,临界值的大小与地域、年龄、性别、身体质量指数、握力等有关,其作为营养状态评估工具可弥补传统评估的弊端,特异度和敏感度较高。结论:低PA与营养状态受损有关,PA可能成为癌症患者生存的主要预后因素,这一新工具的推广为提高癌症治愈率和改善预后提供了更大可能性。
Objective:To systematically evaluate the sensitivity of phase angle(PA)in detecting malnutrition status in cancer patients,and to summarize the critical value characteristics and influencing factors of phase angle in different cancer populations.Methods:Clinical studies on the application of phase angle in the detection of malnutrition in cancer patients were searched using keywords from China National Knowledge Infrastructure(CNKI),Wanfang Data Knowledge Service Platform,VIP,PubMed,Web of Science,Cochrane Library and Embase.Search period:from the database’s establishment to July 2024.Data was extracted from the selected clinical controlled trials.The latest research and application of phase angle values in clinical practice were summarized,and the characteristics and influencing factors of PA threshold values for different cancer patient groups were explored and comprehensively evaluated.Results:As a result,a total of 19 related studies were included in this article,with a total of 3280 participants suffering from different types and stages of cancer.The overall quality of the selected literature was high.4 studies clearly defined the PA threshold for malnutrition.5 studies identified independent factors affecting PA values and related complications of low PA values.6 studies clearly indicated the association between PA values and survival rate.6 studies combined PA with other indicators to predict the risk of malnutrition.The results showed that PA,as an objective indicator for evaluating nutritional status,can be used to evaluate cell membrane status and human nutritional status.It was positively correlated with cancer survival rate.The size of the critical value was related to region,age,gender,BMI and grip strength,etc.As a nutritional status assessment tool,PA could compensate for the shortcomings of traditional assessment,with high specificity and sensitivity.Conclusion:Low phase angle is associated with impaired nutritional status,and may become the main prognostic factor for cancer patients.The promotion of this new tool provides greater possibilities for improving cancer cure rates and prognosis.
作者
赵鑫
侯治攀
王志江
Zhao Xin;Hou Zhipan;Wang Zhijiang(Department of Rehabilitation Medicine,The Second Affiliated Hospital of Air Force Military Medical University,Xi’an,Shaanxi,710038,China)
出处
《黑龙江医学》
2025年第15期1910-1914,共5页
Heilongjiang Medical Journal
关键词
癌症
营养状况
相位角
Cancer
Nutritional status
Phase angle
