摘要
目的 评估超高场5.0T MRI结合多定量参数直方图分析鉴别诊断前列腺癌和良性前列腺增生的效能。资料与方法 回顾性分析2024年1—5月重庆大学附属三峡医院63例经穿刺或手术病理确诊的前列腺疾病患者的5.0T MRI数据,其中前列腺癌31例、良性前列腺增生32例。MRI序列包括T2WI、T1WI、扩散加权成像、体素内不相干运动和T2 mapping,计算表观扩散系数、真性扩散系数、伪扩散系数、灌注分数和T2 mapping影像指标的直方图参数,并采用受试者工作特征曲线下面积评估诊断效能。结果 前列腺癌的表观扩散系数、真性扩散系数、伪扩散系数、灌注分数和T2 mapping的多个直方图特征第10百分位数、第90百分位数均值、中位数和最小值明显低于良性前列腺增生,差异有统计学意义(Z=-6.036~-3.368,P<0.05),其中表观扩散系数-体素内不相干运动-T2 mapping联合模型的曲线下面积为0.987,敏感度和特异度分别为96.77%和96.87%。结论5.0T MRI多定量参数直方图分析鉴别前列腺癌和良性前列腺增生具有显著诊断效能。
Purpose To evaluate the efficacy of ultra-high field 5.0T MRI combined with histogram analysis for diagnosing prostate cancer and benign prostatic hyperplasia.Materials and Methods This retrospective analysis included data from 63 patients with prostatic diseases at the Chongqing University Three Gorges Hospital from January to May 2024,comprising 31 cases of prostate cancer and 32 cases of benign prostatic hyperplasia.MRI sequences included T2WI,T1WI,diffusion-weighted imaging,intravoxel incoherent motion and T2 mapping.Histogram data of apparent diffusion coefficient,true diffusion coefficient,pseudo-diffusion coefficient,perfusion fraction and T2 relaxation time were calculated,and diagnostic efficacy was assessed using the area under the receiver operating characteristic curve.Results In prostate cancer,the 10th percentile,the 90th percentile,mean,median,and minimum values of histogram parameters from apparent diffusion coefficient,true diffusion coefficient,pseudo-diffusion coefficient,perfusion fraction and T2 mapping were significantly lower than those of benign prostatic hyperplasia(Z=-6.036--3.368,all P<0.05).Notably,the combined model of apparent diffusion coefficient,intravoxel incoherent motion and T2 mapping parameters achieved an the area under the curve of 0.987,with sensitivity and specificity of 96.77%and 96.87%,respectively.Conclusion This study confirms that 5.0T MRI histogram analysis technique demonstrates significant diagnostic efficacy in differentiating prostate cancer from benign prostatic hyperplasia.
作者
郑成凤
邢森
刘兴华
曾文兵
向绍鑫
马欢
ZHENG Chengfeng;XING Sen;LIU Xinghua;ZENG Wenbing;XIANG Shaoxin;MA Huan(Department of Radiology,Chongqing University Three Gorges Hospital,Chongqing 404000,China;不详)
出处
《中国医学影像学杂志》
北大核心
2025年第7期723-729,共7页
Chinese Journal of Medical Imaging
基金
重庆市技术创新与应用发展科技扶贫专项(cstc2019jscx-kjfpX0005)。
关键词
前列腺肿瘤
前列腺增生
磁共振成像
扩散加权成像
超高场强
ROC曲线
曲线下面积
诊断
鉴别
Prostatic neoplasms
Prostatic hyperplasia
Magnetic resonance imaging
Diffusion-weighted imaging
Ultra-high field
ROC curve
Area under curve
Diagnosis,differential
