摘要
目的探讨揿针联合银杏叶提取物注射液治疗难治性突发性耳聋的临床疗效。方法纳入难治性突发性耳聋患者100例,按随机数表法分为观察组与对照组,各50例。对照组在局部糖皮质激素治疗基础上联合银杏叶提取物注射液治疗,观察组在对照组治疗基础上联合揿针治疗。2组均连续治疗2周。观察2组治疗前后中医证候积分,耳鸣分级及评分量表(TEQ)评分,耳鸣残疾评估量表(THI)评分,纯音听阈值,血液流变学指标,血清炎症指标可溶性血管细胞黏附分子-1(sVCAM-1)、基质金属蛋白酶2(MMP-2)、胱抑素C(Cys-C)、C反应蛋白(CRP)的变化,比较2组临床疗效总有效率和不良反应。结果治疗后,2组中医证候积分、TEQ评分、THI评分、500~4000 Hz频率听力阈值、全血黏度、纤维蛋白原、红细胞压积、血浆黏度、sVCAM-1、MMP-2、Cys-C、CRP水平均降低,且观察组低于对照组(P<0.05);观察组临床疗效总有效率(90.00%,45/50)高于对照组(70.00%,35/50)(P<0.05);2组治疗期间均未发生与治疗方案相关不良反应。结论揿针联合银杏叶提取物注射液干预能够提高难治性突发性耳聋临床疗效,改善血液流变学,调控炎症反应,增强内耳微循环,促进听力恢复。
Objective To explore the clinical efficacy of press-needle combined with Ginkgo biloba extract injection in the treatment of refractory sudden deafness.Methods 100 patients with refractory sudden deafness were included and divided into the observation group and the control group according to random number table method,with 50 cases in each group.On the basis of local glucocorticoid treatment,the control group was treated with Ginkgo biloba extract injection,while the observation group was treated with press-needle on the basis of the treatment of the control group.Both groups were treated for two consecutive weeks.The changes in traditional Chinese medicine(TCM)syndrome scores,tinnitus grading and Tinnitus Evaluation Questionnaire(TEQ)scores,Tinnitus Handicap Inventory(THI)scores,pure tone hearing thresholds,hemorheological parameters,and serum inflammatory markers[soluble vascular cell adhesion molecule-1(sVCAM-1),matrix metalloproteinase-2(MMP-2),cystatin C(Cys-C),C-reactive protein(CRP)]before and after treatment in both groups were observed.The total effective rate and adverse reactions between two groups were compared.Results TCM syndrome scores,TEQ scores,THI scores,hearing thresholds at 500-4000 Hz frequencies,whole blood viscosity,fibrinogen,hematocrit,plasma viscosity,and the levels of sVCAM-1,MMP-2,Cys-C and CRP decreased,and the observation group was lower than the control group(P<0.05);The total effective rate in the observation group(90.00%,45/50)was significantly higher than that in the control group(70.00%,35/50)(P<0.05).There was no adverse reactions during the treatment period in both groups.Conclusion Press-needle combined with Ginkgo biloba extract injection can improve the clinical efficacy of refractory sudden deafness,improve hemorheology,regulate inflammatory response,enhance inner ear microcirculation,and promote hearing recovery.
作者
王欢
郑洁
李福来
冯晨芳
张南
刘颖
王占强
杨斌
刘侃
WANG Huan;ZHENG Jie;LI Fulai;FENG Chenfang;ZHANG Nan;LIU Ying;WANG Zhanqiang;YANG Bin;LIU Kan(Department of Otolaryngology,Cangzhou People's Hospital,Cangzhou 061000,China;Department of Neurology,Cangzhou People's Hospital,Cangzhou 061000,China)
出处
《长春中医药大学学报》
2025年第8期897-902,共6页
Journal of Changchun University of Chinese Medicine
基金
河北省医学科学研究课题计划项目(20220305)。
关键词
难治性突发性耳聋
揿针
银杏叶提取物注射液
血液流变学
炎症反应
refractory sudden deafness
press-needle
Ginkgo biloba extract injection
hemorheology
inflammatory response
