摘要
目的分析云南丽江急性乌头碱中毒的病例特征,为制定有针对性的防治措施提供科学依据。方法回顾性分析2014—2022年昆明理工大学附属丽江市人民医院收治的309例急性乌头碱中毒住院患者的临床资料,采用Excel软件、SPSS27.0软件和χ^(2)检验,分析患者一般特征、中毒情况、药物相关信息、治疗经过及预后。结果309例病例中,男性243例(78.6%)、女性66例(21.4%),男女性别比为3.68:1;45~59岁人群最多(137例,44.3%);口服是中毒的主要途径,中毒原因多为意外;中毒患者以农村、少数民族为主;2014—2017年病例数量持续上升,2017年后逐步下降,至2022年回升,夏、冬季高发;附子是引起中毒最常见的品种;58.2%的患者于夜间21:00至凌晨02:59就诊(夜间定义为20:00至23:59,凌晨为00:00~02:59)。结论云南丽江地区急性乌头碱中毒形势严峻,具有明显的季节性特征,男性、中年、少数民族和农村居民是高发人群,意外中毒占主导,其中以附子中毒占比最高,应加强毒性中药材的管理及宣教。
Objective To analyze the characteristics of acute aconitine poisoning cases in Lijiang,Yunnan,and provide a scientific basis for formulating targeted prevention and control measures.Methods The clinical data from 309 hospitalized patients with acute aconitine poisoning treated at Lijiang People's Hospital Affiliated to Kunming Uni-versity of Science and Technology between 2014 and 2022 were retrospectively analyzed.Excel,SPSS27.0 software,and the χ^(2) test were used to analyze patients'general characteristics,poisoning circumstances,drug-related information,treatment course,and outcomes.Results Among the 309 cases,243(78.6%)were male and 66(21.4%)were female,resulting in a male-to-female ratio of 3.68:1.The 45-59 year age group was the largest(137 cases,44.3%).Oral inges-tion was the primary route of poisoning,and the cause was mostly accidental.Poisoned patients were predominantly from rural areas and ethnic minorities.The number of cases increased continuously from 2014 to 2017,gradually de-clined after 2017,and rebounded in 2022.Poisoning was more frequent in summer and winter.Aconitum carmichaelii(Fuzi)was the most common variety causing poisoning.58.2%of patients sought medical attention between 21:00 and 02:59(night defined as 20:00-23:59;early morning defined as 00:00-02:59).Conclusion Acute aconitine poisoning presents a serious challenge in Lijiang,Yunnan,exhibiting distinct seasonal patterns.Males,middle-aged individuals,eth-nic minorities,and rural residents are high-risk groups.Accidental poisoning predominates,with Aconitum carmichaelii(Fuzi)being the most frequent cause.Management and public education regarding toxic Chinese medicinal materials should be strengthened.
作者
李小继
金琳
海水燕
王文璐
宋建艳
和佳琪
李国荣
LI Xiao-ji;JIN Lin;HAI Shui-yan;WANG Wen-lu;SONG Jian-yan;HE Jia-qi;LI Guo-rong(Department of Pharmacy,Lijiang People's Hospital Affiliated to Kunming University of Science and Technology,Lijiang 674100,Yunnan,CHINA;Department of Gastroenterology,Lijiang People's Hospital Affiliated to Kunming University of Science and Technology,Lijiang 674100,Yunnan,CHINA)
出处
《海南医学》
2025年第16期2399-2402,共4页
Hainan Medical Journal
基金
云南省丽江市社会发展领域科技基金资助项目(编号:ljsf20210003)
昆明理工大学临床教学基地医院自筹联合项目(编号:KUST-LJ2022001Y)
云南省丽江市第八批中青年学术和技术带头人基金资助项目(编号:丽科发[2023]13号)。
关键词
乌头碱中毒
丽江
流行特征
防控
Aconitine poisoning
Lijiang City
Epidemic characteristics
Prevention and control
