摘要
目的探讨宫腔镜冷刀切除术后口服雌二醇/雌二醇地屈孕酮片复合包装(芬吗通)对子宫内膜息肉患者临床疗效及预后的影响。方法采用前瞻性随机对照试验,研究对象为2022年7月至2024年10月于安庆市第二人民医院就诊的94例子宫内膜息肉患者。经随机数字表法分为两组,每组47例。对照组仅接受宫腔镜冷刀切除术,研究组在宫腔镜冷刀切除术后口服芬吗通治疗3个周期。对比分析两组治疗效果以及治疗前后两组患者月经恢复情况、性激素水平和子宫内膜厚度变化,统计两组随访6个月后复发情况。结果研究组临床总有效率达97.87%(46/47),较对照组82.98%(39/47)高(χ^(2)=4.424,P<0.05)。治疗后,研究组月经周期、经期、经期出血量积分[分别为(30.15±3.39)d、(4.62±0.39)d、(103.54±9.43)分]均低于对照组[分别为(32.35±3.76)d、(5.24±0.47)d、(117.28±10.36)分],差异均有统计学意义(t=2.979、6.960、6.724,均P<0.05)。治疗后,研究组子宫内膜厚度、雌二醇(E_(2))、促卵泡生成素(FSH)、黄体生成素(LH)水平[分别为(6.24±0.83)mm、(26.46±3.25)pg·mL^(-1)、(6.49±0.53)mIU·mL^(-1)、(4.81±0.43)mIU·mL^(-1)]均低于对照组[分别为(7.67±0.95)mm、(31.74±3.69)pg·mL^(-1)、(7.05±0.66)mIU·mL^(-1)、(5.06±0.58)mIU·mL^(-1)],差异均有统计学意义(t=7.771、7.362、4.536、2.374,均P<0.05)。研究组复发率为2.13%(1/47),低于对照组的21.28%(10/47)(χ^(2)=8.340,P<0.05)。结论在宫腔镜冷刀切除术后口服芬吗通对子宫内膜息肉的治疗效果较好,能有效调节性激素水平,降低复发率。
Objective To observe the clinical effect of oral estradiol/estradiol dydrogesterone tablets(femoston)on treatment of endometrial polyp patients after hysteroscopic cold knife resection and the impact on prognosis.Methods A prospective randomized controlled trial was adopted.A total of 94 patients with endometrial polyps who visited the Gynecology Department of Anqing Second People’s Hospital from July 2022 to October 2024 were selected as the research subjects and randomly divided into two groups by random number table method,with 47 cases in each group.The control group received hysteroscopic cold knife resection alone and the research group was treated with oral femoston for 3 cycles after hysteroscopic cold knife resection.The therapeutic effects and the menstrual recovery,sex hormone levels and changes in endometrial thickness before and after treatment were compared and analyzed between the two groups.The recurrence rates were statistically analyzed after a 6-month follow-up.Results The overall clinical effective rate in the research group was 97.87%(46/47),higher than 82.98%(39/47)in the control group(χ^(2)=4.424,P<0.05).After the treatment,the levels of menstrual cycle,menstrual period,and amount of menstrual bleeding in the research group were(30.15±3.39)d,(4.62±0.39)d and(103.54±9.43)points,lower than(32.35±3.76)d,(5.24±0.47)d and(117.28±10.36)points in the control group,and there were significant differences between the two groups(t=2.979,6.960,6.724,all P<0.05).After the treatment,the levels of endometrial thickness,estradiol(E_(2)),follicle-stimulating hormone(FSH)and luteinizing hormone(LH)in the research group were(6.24±0.83)mm,(26.46±3.25)pg·mL^(-1),(6.49±0.53)mIU·mL^(-1) and(4.81±0.43)mIU·mL^(-1),respectively,lower than(7.67±0.95)mm,(31.74±3.69)pg·mL^(-1),(7.05±0.66)mIU·mL^(-1) and(5.06±0.58)mIU·mL^(-1) in the control group,and there were significant differences between the two groups(t=7.771,7.362,4.536,2.37,all P<0.05).The recurrence rate was 2.13%(1/47)in the research group,lower than 21.28%(10/47)in the control group(χ^(2)=8.340,P<0.05).Conclusion Oral administration of femoston after hysteroscopic cold knife resection proves effective in treating endometrial polyps,which can regulate sex hormone levels and reduce recurrence rates.
作者
李娟
韩文晖
叶佳佳
Li Juan;Han Wenhui;Ye Jiajia(Department of Obstetrics and Gynecology,Anqing Second People's Hospital,Anqing 246004,China)
出处
《中国药物应用与监测》
2025年第5期865-868,共4页
Chinese Journal of Drug Application and Monitoring
基金
2022年安庆市卫生健康委科研课题(卫宣教〔2022〕298号)。
