摘要
目的探究阿立哌唑联合富马酸喹硫平方案治疗精神分裂症患者的疗效及对患者情绪的影响。方法选择2020年2月至2023年12月于国药中铁精神病医院予以针对性治疗的精神分裂症患者137例,经随机数字表法将其分成两组,对照组(n=69)予以阿立哌唑治疗,联合组(n=68)加用富马酸喹硫平治疗。比较两种方案的临床疗效、治疗前后阳性与阴性症状量表(PANSS)评分、情绪改善情况[汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)]以及用药安全性。结果在治疗总有效率方面,联合组为92.65%(63/68),较对照组的81.16%(56/69)高(χ^(2)=3.960,P=0.040)。在PANSS评分方面,联合组治疗后阳性症状、阴性症状及一般病理评分[分别为(15.48±1.15)分、(14.71±1.54)分、(23.31±1.62)分]均低于对照组[分别为(20.82±1.96)分、(18.72±1.89)分、(29.49±1.68)分],差异均有统计学意义(t=19.413、13.603、21.913,均P<0.05)。在情绪改善方面,联合组治疗后HAMD和HAMA评分[分别为(10.91±1.14)分、(12.89±2.15)分]均低于对照组[分别为(13.02±1.19)分、(17.17±3.89)分],差异均有统计学意义(t=10.595、7.954,均P<0.05)。对照组不良反应发生率为24.64%(17/69),联合组为25.00%(17/68),两组比较差异无统计学意义(χ^(2)=0.002,P=0.961)。结论富马酸喹硫平联合阿立哌唑治疗精神分裂症患者可提升疗效,改善阳性与阴性症状以及负性情绪,且安全性可控。
Objective To evaluate the therapeutic efficacy of aripiprazole combined with quetiapine in patients with schizophrenia and to assess its effects on emotional regulation.Methods 137 patients with schizophrenia treated in Sinopharm China Railway Psychiatric Hospital from February 2020 to December 2023 were selected and randomly divided into 2 groups using the random number method.The control group(n=69)received aripiprazole,and the combined group(n=68)received aripiprazole combined with quetiapine.The clinical efficacy,pre-and post-treatment positive and negative symptom scale(PANSS)scores,emotion regulation status(Hamilton Depression Rating Scale(HAMD),Hamilton Anxiety Rating Scale(HAMA))and medication safety of the two regimens were compared.Results The combined group achieved a total effective rate of 92.65%(63/68),significantly higher than the 81.16%(56/69)observed in the control group(χ^(2)=3.960,P=0.040).In terms of PANSS score,the positive symptoms,negative symptoms and general pathology scores of the combined group after treatment((15.48±1.15)points,(14.71±1.54)points,(23.31±1.62)points)were lower than those of the control group((20.82±1.96)points,(18.72±1.89)points,(29.49±1.68)points),and the differences were statistically significant(t=19.413,13.603,21.913,all P<0.05).In terms of emotion regulation,the HAMD and HAMA scores of the combined group after treatment were((10.91±1.14)and(12.89±2.15)respectively),which were lower than those of the control group((13.02±1.19)and(17.17±3.89)respectively),with statistically significant differences(t=10.595,7.954,both P<0.05).The incidence of adverse reactions in the control group was 24.64%(17/69),and that in the observation group was 25.00%(17/68),there was no statistically significant difference between the two groups(χ^(2)=0.002,P=0.961).Conclusion Quetiapine combined with aripiprazole in the treatment of schizophrenia can enhance its efficacy,improve positive and negative symptoms and negative emotions,and the safety is controllable.
作者
孙媛媛
汪洁
李晓哲
吴君益
Sun Yuanyuan;Wang Jie;Li Xiaozhe;Wu Junyi(Department of Psychiatry,Sinopharm China Railway Psychiatric Hospital,Hefei 230011,China)
出处
《中国药物应用与监测》
2025年第5期797-800,共4页
Chinese Journal of Drug Application and Monitoring
关键词
阿立哌唑
富马酸喹硫平
精神分裂症
阳性症状
阴性症状
负性情绪
Aripiprazole
Quetiapine fumarate
Schizophrenia
Positive symptoms
Negative symptoms
Negative emotions
