摘要
目的观察超脉冲CO_(2)点阵激光联合光子嫩肤治疗凹陷性痤疮瘢痕疗效及对皮肤屏障指标、瘢痕面积和痤疮瘢痕临床评分量表(ECCA)评分的影响。方法选取2022年9月至2024年.9月烟台市烟台山医院就诊的凹陷性痤疮瘢痕患者148例,采用随机数表法分为联合组(74例)和对照组(74例),对照组给予超脉冲CO_(2)点阵激光治疗,联合组在超脉冲CO_(2)点阵激光治疗2周后加用光子嫩肤治疗,两组均治疗3次,每次间隔4周,比较两组末次治疗后3个月临床疗效,以及治疗前后皮肤屏障功能、瘢痕面积、ECCA评分、皮肤色度及不良反应。结果治疗后3个月,联合组总有效率高于对照组(P<0.05);两组经皮水分丢失率(TEWL)、ECCA评分及皮肤色度a*值均较治疗前显著降低(P<0.05),且联合组低于对照组(P<0.05),角质层含水量(SCH)及皮肤色度L*值均较治疗前升高(P<0.05),且联合组高于对照组;两组瘢痕面积均较显著减小(P<0.05),且联合组小于对照组(P<0.05);联合组色素沉着发生率低于对照组(P<0.05)。结论超脉冲CO_(2)点阵激光联合光子嫩肤治疗凹陷性痤疮瘢痕疗效确切,可以更有效改善皮肤屏障功能,减小瘢痕面积,降低ECCA评分,并改善皮肤色度,减少色素沉着风险,安全性良好。
Objective To observe the efficacy of ultra-pulsed CO_(2) fractional laser combined with photorejuvenation in the treatment of atrophic acne scars and its effects on skin barrier indicators,scar area,and Echelle d'évaluation clinique des cicatrices d'acné(ECCA)score.Methods A total of 148 patients with atrophic acne scars treated at Yantai Mountain Hospital were selected from September 2022 to September 2024.They were divided into a combined group(74 cases)and a control group(74 cases)using a random number table.The control group received ultra-pulsed CO_(2) fractional laser treatment,while the combined group received photorejuvenation 2 weeks after the ultra-pulsed CO_(2) fractional laser treatment.Both groups underwent 3 treatment sessions at 4-week intervals.Clinical efficacy at 3 months after the final treatment,skin barrier function,scar area,ECCA score,skin chroma,and adverse reaction Incidence were compared between the two groups before and after treatment.Results At 3 months post-treatment,the total effective rate was higher in the combined group than in the control group(P<0.05).Transepidermal water loss(TEWL),ECCA scores,and skin chroma a*values significantly decreased in both groups compared to pretreatment levels(P<0.05),with the combined group showing lower values than the control group(P<0.05).Stratum corneum hydration(SCH)and skin chroma L*values increased compared to pretreatment levels(P<0.05),with higher values in the combined group(P<0.05).Scar area significantly decreased in both groups(P<0.05),with a smaller area in the combined group(P<0.05).The incidence of pigmentation was lower in the combined group than in the control group(P<0.05).Conclusion Ultra-pulsed CO_(2) fractional laser combined with photorejuvenation is effective for treating atrophic acne scars.It better improves skin barrier function,reduces scar area,lowers ECCA scores,improves skin chroma,and decreases the risk of pigmentation,demonstrating good safety.
作者
孙晓红
秦秀美
马海丽
刘小亮
姜美玉
李露霄
SUN Xiaohong;QIN Xiumei;MA Haili;LIU Xiaoliang;JIANG Meiyu;LI Luxiao(Department of Dermatology,Yantai Mountain Hospital,Yantai,Shandong 264000,China)
出处
《转化医学杂志》
2025年第7期117-120,共4页
Translational Medicine Journal
基金
烟台市科技计划项目(2020YD037)。
