摘要
随着糖代谢异常领域研究的持续深入,糖尿病前期(prediabetes mellitus,PDM)作为糖尿病发展的关键阶段,会导致大脑结构和功能异常,增加认知障碍的风险,成为当前糖代谢异常医学领域亟待攻克的重大公共卫生课题。目前,针对PDM所致脑组织结构及功能异常的病理生理机制,尚未形成完全明确的阐释,其影像学特征也缺乏系统性研究结论。在此背景下,借助无创性MRI技术实现PDM相关脑损伤的早期诊断与干预,具备重要临床实践价值。近年来,MRI及其衍生技术在PDM相关脑损伤的发病机制探究和临床诊断工作中,已逐渐展现出不可替代的显著优势。本文系统梳理了基于多模态MRI技术的PDM脑部结构及功能改变研究进展,同时指出当前研究存在的不足,探讨未来研究方向,旨在为阐述PDM相关认知功能障碍的病理机制、优化临床治疗决策提供新的思路。
With the continuous deepening of research in the field of glucose metabolism disorders,prediabetes mellitus(PDM),as a critical stage in the development of diabetes,can lead to abnormalities in brain structure and function,increasing the risk of cognitive impairment and thus becoming a major public health issue urgently needing to be addressed in the current medical field of glucose metabolism disorders;at present,the pathophysiological mechanisms underlying PDM-induced abnormalities in brain tissue structure and function have not yet been fully clarified,and there is a lack of systematic research conclusions on its imaging characteristics,against which background the use of non-invasive MRI technology to achieve early diagnosis and intervention of PDM-related brain injury holds important clinical practical value;in recent years,MRI and its derivative technologies have gradually demonstrated irreplaceable and significant advantages in exploring the pathogenesis and clinical diagnosis of PDM-related brain injury,and this article systematically reviews the research progress on PDM-related changes in brain structure and function based on multimodal MRI techniques,while pointing out the limitations of current research and exploring future research directions,aiming to provide new insights for elaborating the pathological mechanisms of PDM-related cognitive impairment and optimizing clinical treatment decisions.
作者
向雨
杨思懿
田斌
何青
李仕广
XIANG Yu;YANG Siyi;TIAN Bin;HE Qing;LI Shiguang(College of Medical Imaging,Guizhou Medical University,Guiyang 550004,China;Department of Imaging,the Second People's Hospital of Guiyang,Guiyang 550081,China)
出处
《磁共振成像》
北大核心
2025年第8期143-147,167,共6页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金项目(编号:82360337)。
关键词
糖尿病前期
脑结构
磁共振成像
静息态功能磁共振成像
扩散张量成像
灰质
白质
类淋巴系统
prediabetes mellitus
brain structure
magnetic resonance imaging
resting-state functional magnetic resonance imaging
diffusion tensor imaging
gray matter
white matter
glymphatic system
