摘要
目的本研究采用文献计量学及知识图谱的方法对百日咳研究领域的主要研究热点及趋势进行系统的梳理和可视化分析,总结本领域研究方向、梳理知识结构,为后续研究提供指导与参考。方法在Pubmed、Web of science核心集、Scopus中检索百日咳研究领域的文献,检索限定文献发表时间为1975年1月1日至2024年12月31日,运用文献计量学软件Vosviewer 1.6.18及R语言Bibliometrix包对发表文献的作者、机构、国家、高影响力期刊和高被引文献以及关键词等多个方面进行系统分析,总结百日咳研究领域的研究热点、前沿及趋势。结果共检索得到文献89543篇,经过合并去重及筛选纳入文献26651篇,从研究趋势上看百日咳领域文献发表量总体呈波动上升趋势;发文数量最多的研究者是Wang Y,发文量为156篇;15029个机构参与发表论文,发表10篇以上论文的机构1320个,总发文量最多的机构为葛兰素史克公司583篇,加州大学系统发文量排第2为527篇,但其总被引次数最高为13955次,综合影响力最高;总发文量排名前3的国家和地区为美国(19699篇)、日本(4485篇)、法国(4039篇);发文量最多的期刊是Vaccine为2146篇,其影响力也最高;通过对关键词聚类图谱结果进行分析发现,百日咳研究领域的文献2个主要方向前期为百日咳的毒性与致病机制基础研究,之后为疫苗相关研究。结论百日咳作为一种全球性的传染病,主要研究方向前期主要集中在百日咳的毒性及致病机制为主的基础研究,之后研究重心逐渐转移到百日咳疫苗相关研究。鉴于百日咳在可预见的未来仍将继续存在,百日咳的发病高峰年龄已从婴儿期转移到未提供加强疫苗接种的青少年及成人,漏检和假阳性、关键细菌位点的突变以及青少年和成年人作为传染源的重要性尚未得到重视,因此百日咳未来主要研究方向应侧重在完善疾病监测系统、关注细菌变异用于耐药、加快疫苗升级和研发,优化儿童、成人及孕妇的免疫接种策略。
Objective This study systematically analyzes and visualizes the main research hotspots and trends in the field of pertussis research through bibliometrics and knowledge map methods,summarizes the research directions and knowledge framework in this field,and provides guidance and reference for subsequent research.Methods Pertussis-related literature published between January 1,1975,and December 31,2024,was retrieved from PubMed,the Web of Science Core Collection,and Scopus.The bibliometric software VOSviewer(version 1.6.18)and R software Bibliometrix package were used to systematically analyze the research authors,institutions,countries,high impact journals,highly cited literature,and keywords,in order to summarize the research hotspots,frontiers,and trends in the field of pertussis research.Results A total of 89543 articles were initially retrieved,of which 26651 articles were included after merging,deduplication,and screening.From the research trend,the overall publication volume in the field of pertussis showed a fluctuating upward trend;The researcher with the highest number of publications is Wang Y,with 156 articles.Fifteen thousand and twenty-nine institutions participated in publishing papers,with 1320 institutions publishing more than 10 papers.The institution with the highest total publication volume was GlaxoSmithKline with 583 papers,and the University of California System ranked second with 527 papers.However,its total citation score was the highest at 13955,indicating the highest overall influence;The top three countries and regions in terms of publication volume are USA(19699),Japan(4485),and France(4039);The journal with the highest publication volume is Vaccine,with 2146 articles and the highest influence;Through the analysis of the keyword clustering map results,it was found that the literature in the field of pertussis research has 2 main directions:the basic research on the toxicity and pathogenic mechanism of pertussis in the early stage,and the vaccine related research in the later stage.Conclusions As a global infectious disease,pertussis has mainly focused on basic research on its toxicity and pathogenic mechanisms in the early stage,and gradually shifted its research focus to pertussis vaccine related research.Given that pertussis will continue to exist in the foreseeable future,the peak age of onset for pertussis has shifted from infancy to adolescents and adults who have not received strengthened vaccinations.Omission and false positives,mutations in key bacterial sites,and the importance of adolescents and adults as sources of infection have not been given enough attention.Therefore,the main research direetions for pertussis in the future should focus on improving disease surveillance systems,paying attention to bacterial mutations for drug resistance,accelerating vaccine upgrades and development,and optimizing immunization strategies for children,adults,and.pregnant women.
作者
李丽
艾红军
马瑜
裴婷婷
付强强
LI Li;AI Hongjun;MA Yu;PEI Tingting;FU Qiangqiang(Emergency Management Office,Shanghai Changning District Center for Disease Control and Prevention,200335,China)
出处
《传染病信息》
2025年第4期385-393,共9页
Infectious Disease Information
基金
上海市长宁区科委医疗卫生科研专项(CNKW2024Y41)
上海市加强公共卫生体系建设三年行动计划重点学科传染病学(GWVI-11.1-01)。
关键词
百日咳
趋势
热点
文献计量
知识图谱
pertussis
trends
hot spots
bibliometrics
knowledge map
