摘要
目的:探讨家庭护士食疗理论应用于肺癌化疗病人的临床效果。方法:选择2024年6月—12月在山西省某三级甲等医院肿瘤科化疗病人73例,随机分为对照组35例与观察组38例。最终观察组35例、对照组35例病人完成试验。对照组根据《肿瘤病人营养支持指南》制定食谱,观察组采用基于家庭护士食疗理论的家庭护士食疗方案,制定个性化食谱。干预6周后比较两组病人炎症指标[白细胞介素-2(IL-2)、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)、干扰素-γ(IFN-γ)]、营养指标[总蛋白(TP)、白蛋白(ALB)、球蛋白(GLB)、血红蛋白(Hb)]、抗氧化指标(超氧化物歧化酶)、代谢指标[空腹血糖、空腹胰岛素、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、安全性指标[丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、肌酐、尿素],评估两组肿瘤病人生命质量测定量表(FACT-G)、病人主观整体营养状况自评量表(PG-SGA)得分以及化疗后消化道不良反应发生情况。结果:干预6周后,观察组TP、ALB高于对照组,IL-6、IFN-γ、ALT、AST低于对照组;FACT-G得分高于对照组,PG-SGA评分低于对照组;化疗不良反应总发生率低于对照组,差异均有统计学意义(P<0.05)。结论:验证了家庭护士食疗理论在肺癌化疗病人抗炎、抗氧化、调整代谢中的有效性。
Objective:To explore the clinical effect of the application of the family nurse dietary therapy theory in lung cancer patients undergoing chemotherapy.Methods:A total of 73 patients who underwent chemotherapy in the oncology department of a tertiary grade A hospital in Shanxi province from June to December 2024 were selected,and randomly divided into the control group of 35 cases and the observation group of 38 cases.The final observation group of 35 patients and the control group of 35 cases completed the trial.The control group formulated the diet plan according to the"Nutritional support guidelines for cancer patients".The observation group adopted the family nurse dietary therapy program based on family nurse dietary therapy theory,and formulated personalized diet plans.After six weeks of intervention,the inflammatory indicators,nutritional indicators,metabolic indicators and safety indicators of the two groups of patients were compared.Inflammatory indicators included interleukin⁃2(IL⁃2),interleukin⁃4(IL⁃4),interleukin⁃6(IL⁃6),interleukin⁃10(IL⁃10),tumor necrosis factor⁃α(TNF⁃α),C⁃reactive protein(CRP),and interferon⁃γ(IFN⁃γ).Nutritional indicators included total protein(TP),albumin(ALB),globulin(GLB),hemoglobin(Hb).Antioxidant indicators included superoxide dismutase(SOD).Metabolic indicators included fasting blood glucose,fasting insulin,total cholesterol(TC),triglycerides(TG),high⁃density lipoprotein cholesterol(HDL⁃C),and low⁃density lipoprotein cholesterol(LDL⁃C).Safety indicators include alanine aminotransferase(ALT),aspartate aminotransferase(AST),creatinine,and urea.The Functional Assessment of Cancer Therapy⁃General(FACT⁃G)scores,the Patient Generated Subjective Global Assessment(PG⁃SGA)scores and the occurrence of adverse digestive tract reactions after chemotherapy of the two groups of patients were evaluated.Results:After 6 weeks of intervention,TP and ALB in the observation group were higher than those in the control group,and IL⁃6,IFN⁃γ,ALT and AST in the observation group were lower than those in the control group.The FACT⁃G score of the observation group was higher than that of the control group.The PG⁃SGA score of the observation group was lower than that of the control group.The total incidence of adverse chemotherapy reactions in the observation group was lower than that in the control group.There were differences statistical significant between the two groups(all P<0.05).Conclusions:This study verified the effectiveness of the family nurse dietary therapy theory in anti⁃inflammation,antioxidation and metabolic regulation in lung cancer patients undergoing chemotherapy.
作者
姚晓利
韩世范
程洁
赵奕雯
程俊香
王效华
赵瑜
宋杰
朱瑞芳
YAO Xiaoli;HAN Shifan;CHENG Jie;ZHAO Yiwen;CHENG Junxiang;WANG Xiaohua;ZHAO Yu;SONG Jie;ZHU Ruifang(Nursing College of Shanxi Medical University,Shanxi 030001 China;Dietotherapy Science and Technology Research Center,Shanxi Medical University;Shanxi Province Food Therapy and Agricultural Products Prescription Industry Technology Innovation Strategic Alliance;Major Platform Carrier and Training Base for the Integration of Health Industry and Education in Shanxi Province;First Hospital of Shanxi Medical University;Shanxi Traditional Chinese Medical Hospital;Shanxi Medical Periodical Press Co.,Ltd.)
出处
《护理研究》
北大核心
2025年第16期2694-2701,共8页
Chinese Nursing Research
关键词
家庭护士食疗理论
肺癌
化疗
生活质量
营养干预
临床观察
护理
family nurse dietary therapy theory
lung cancer
chemotherapy
quality of life
nutritional intervention
clinical observation
nursing
