摘要
与小分子药物相比,蛋白质药物具有特异性高、毒性小的优点,在许多重大疾病的治疗中发挥重要作用.但蛋白质药物在临床应用中也面临诸多挑战,如稳定性差,免疫原性强,易被快速降解、清除等,最终导致其生物利用度低.为此,人们构建了多种蛋白质药物递送体系以解决上述问题.利用动态共价键构建的递送体系不仅能提高蛋白质药物在递送过程中的稳定性,还能实现病灶部位的刺激响应性药物释放,有效提高蛋白质药物的生物利用度和治疗效果.本文概述了利用共价键、非共价相互作用以及动态共价键构建的蛋白质药物递送体系,重点介绍了基于动态共价键的蛋白质药物递送体系的构建方法、药物释放机制以及最新应用研究进展,以期为开发更加高效、实用的蛋白质药物递送体系提供借鉴.
Compared to small molecule drugs,protein drugs exhibit high specificity and low toxicity,making them pivotal in the treatment of numerous serious diseases.Nevertheless,they confront several challenges in clinical application,including instability,high immunogenicity,and susceptibility to rapid degradation and elimination,ultimately resulting in low bioavailability.To overcome these problems,various protein drug delivery systems have been devised.Notably,delivery systems utilizing dynamic covalent bonds not only increase the stability of protein drugs during the delivery process but also facilitate stimulus-responsive drug release at the target site,thereby significantly enhancing the bioavailability and therapeutic efficacy of protein drugs.This review briefly introduces protein drug delivery systems based on covalent bonds,non-covalent interactions,and dynamic covalent bonds.The construction methodologies,drug release mechanisms,and the latest advancements in the application of protein drug delivery systems based on dynamic covalent bonds are then summerized.The aim is to provide insights and guidance for the development of more efficient and practical protein drug delivery systems.
作者
何苏宁
刘赛男
张婷婷
史林启
马如江
Su-ning He;Sai-nan Liu;Ting-ting Zhang;Lin-qi Shi;Ru-jiang Ma(Key Laboratory of Functional Polymer Materials of Ministry of Education,Institute of Polymer Chemistry,College of Chemistry,Nankai University,Tianjin 300071)
出处
《高分子学报》
北大核心
2025年第8期1293-1312,共20页
Acta Polymerica Sinica
基金
国家自然科学基金(基金号52103183)
国家重点研发计划(项目号2022YFA12057000)
天津市科技计划项目(项目号23JCYBJC01780)资助。
关键词
蛋白质药物
动态共价键
药物递送
刺激响应释放
纳米载体
Protein drugs
Dynamic covalent bonds
Drug delivery
Stimulus-responsive release
Nanocarriers
