摘要
钕(Nd)是重要的稀土元素之一,现已被广泛应用于工业、农业、医学等领域中。钕及其化合物可通过大气、土壤、食物等途径暴露进入人体,在体内蓄积导致多种毒性效应。然而,目前关于稀土钕的毒性效应及其机制的研究尚少。本文介绍了稀土元素钕对肝脏、肺和其他脏器的毒性效应及其作用机制,归纳了稀土元素钕的遗传毒性、生殖毒性、神经毒性及其对内分泌系统的影响,以期为未来职业暴露和环境污染中钕的长期低剂量暴露的毒性效应提出参考依据。
Neodymium,one of the important rare earth elements,is widely used in various fields such as industry,agriculture,and medicine.Neodymium and its compounds can accumulate in the human body through exposure to air,soil,food and so on,leading to various toxic effects.However,research on the toxicity effects and mechanisms of neodymium is still limited.This review summarized the toxic effects of neodymium on the liver,lung,and other organs,and discussed its genotoxicity,reproductive toxicity,neurotoxicity,and impacts on the endocrine system.The aim is to provide references for revealing the toxic effects of long-term low-dose exposure to neodymium in occupational exposure and environmental pollution scenarios.
作者
冷静
王宁
洪新宇
LENG Jing;WANG Ning;HONG Xinyu(Institute of Chemical Toxicity Testing/NHC Specialty Laboratory of Food,Safety Risk Assessment and Standard Development/State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants,Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China)
出处
《环境与职业医学》
北大核心
2025年第6期770-773,共4页
Journal of Environmental and Occupational Medicine
基金
上海市加强公共卫生体系建设三年行动计划(2023—2025年)重点学科建设项目(GWVI-11.1-41、42)
上海市加强公共卫生体系建设三年行动计划项目(2023—2025年)(GWVI-4)
上海市疾病预防控制中心第四批中心青年科技人才培养“青耕计划”项目(青耕2024-37)。
关键词
稀土元素
钕
毒性效应
遗传毒性
生殖毒性
神经毒性
rare earth element
neodymium
toxic effect
genotoxicity
reproductive toxicity
neurotoxicity
