摘要
目的探讨丁螺环酮片联合艾司西酞普兰治疗抑郁症(DD)伴焦虑患者的效果。方法选取萍乡市第二人民医院2023年4月至2024年7月收治的DD伴焦虑患者98例,以随机数字表法分为两组,各49例;对照组单用艾司西酞普兰治疗,试验组用丁螺环酮片联合艾司西酞普兰治疗,对比两组的临床疗效、抑郁与焦虑情绪、血清炎症因子水平、认知功能及不良反应。结果试验组总治疗有效率[91.84%(45/49)]较对照组[75.51%(37/49)]高(P<0.05);治疗后,试验组汉密尔顿抑郁量表(HAMD)评分、汉密尔顿焦虑量表(HAMA)评分、白细胞介素(IL)-1β、肿瘤坏死因子-α(TNF-α)水平分别为(9.10±1.55)分、(6.54±1.02)分、(78.54±4.84)pg/mL、(4.11±0.51)pg/mL,均较对照组[(12.54±2.64)分、(8.94±1.95)分、(91.53±5.62)pg/mL、(6.75±0.82)pg/mL]低,IL-10水平、蒙特利尔认知评估量表(MoCA)评分分别为(25.74±2.96)pg/mL、(27.85±1.02)分,均较对照组[(20.44±1.97)pg/mL、(26.11±0.95)分]高(P<0.001);试验组不良反应发生率[14.29%(7/49)]与对照组[10.20%(5/49)]相比无统计学差异(P>0.05)。结论丁螺环酮片联合艾司西酞普兰治疗DD伴焦虑患者效果较好,可缓解抑郁与焦虑情绪,减轻炎症反应,改善认知功能,且安全性好。
Objective To explore the efficacy of buspirone tablets combined with escitalopram in the treatment of patients with depression(DD)and anxiety.Methods Ninety-eight patients with DD and anxiety admitted to The Second People's Hospi-tal of Pingxiang City from April 2023 to July 2024 were selected and divided into two groups by randomized number table method,with 49 cases in each group.The control group was treated with escitalopram alone,and the experimental group was treated with buspirone tablets combined with escitalopram.The clinical efficacy,depression and anxiety,serum level of inflammatory factor,cognitive function,and adverse reactions of the two groups were compared.Results The total treatment effectiveness rate of the experimental group[91.84%(45/49)]was higher than that of the control group[75.51%(37/49)](P<0.05).After treat-ment,the Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA)scores,interleukin(IL)-1β,and tumor necrosis factor-α(TNF-α)levels of the experimental group were(9.10±1.55)points,(6.54±1.02)points,(78.54±4.84)pg/mL,and(4.11±0.51)pg/mL,respectively,which were lower than those in the control group[(12.54±2.64)points,(8.94±1.95)points,(91.53±5.62)pg/mL,and(6.75±0.82)pg/mL].IL-10 levels and Montreal Cognitive Assessment Scale(MoCA)scores were(25.74±2.96)pg/mL and(27.85±1.02)points,respectively in the experimental group,which were higher than those in the control group[(20.44±1.97)pg/mL and(26.11±0.95)points](P<0.001).The relevant ad-verse reactions in the experimental group[14.29%(7/49)]showed no statistically significant difference compared to the control group[10.20%(5/49)](P>0.05).Conclusion Buspirone tablets combined with escitalopram is effective in the treatment of patients with DD and anxiety,relieving depression and anxiety,reducing inflammatory response,improving cognitive function,and the drug safety is good.
作者
余可
宋盛萍
欧阳伟
YU Ke;SONG Shengping;OUYANG Wei(Department of Psychiatry,The Second People's Hospital of Pingxiang City,Pingxiang Jiangxi 337000,China)
出处
《天津药学》
2025年第7期811-814,共4页
Tianjin Pharmacy
