摘要
目的 探讨血清5-羟色胺(5-HT)与IL-6水平在阿尔茨海默病(AD)患者伴发抑郁症中的预测价值。方法 前瞻性纳入96例AD不伴抑郁症的患者,对其随访2年,根据随访期间是否伴发抑郁症将其分为AD伴发抑郁症组(抑郁症组)与AD不伴发抑郁症组(非抑郁症组),比较2组患者基线资料以及基线血清5-HT、IL-6、脑源性神经营养因子(BDNF)与糖皮质激素(GC)水平。对血清5-HT、IL-6水平与汉密尔顿抑郁量表(HAMD)评分进行Pearson相关分析。采用logistics回归分析评估血清5-HT及IL-6水平对AD患者伴发抑郁症的影响,并绘制受试者操作特征(ROC)曲线。结果 剔除9例患者后最终纳入87例患者。抑郁症组(37例)与非抑郁症组(50例)的基线资料具可比性(P均> 0.05)。抑郁症组血清5-HT水平低于非抑郁症组,血清IL-6水平高于非抑郁症组(P均<0.01)。血清5-HT水平与HAMD评分呈负相关(r=-0.572, P <0.01),血清IL-6水平与HAMD评分呈正相关(r=0.609, P <0.01)。血清5-HT水平为AD患者伴发抑郁症的保护因素,血清IL-6水平为危险因素(P均<0.05)。以血清5-HT水平绘制的ROC曲线的曲线下面积(AUC)为0.747,灵敏度为64.00%,特异度为86.49%。血清IL-6水平的AUC为0.732,灵敏度为78.42%,特异度为67.57%。血清5-HT水平联合血清IL-6水平构建的AUC为0.790,灵敏度为76.75%,特异度为87.71%。结论 血清5-HT水平和血清IL-6水平异常与AD患者伴发抑郁症相关,两者联合可用于预测AD患者抑郁症的发生。
Objective To investigate the value of serum 5-hydroxytryptamine(5-HT) and interleukin-6(IL-6) levels in predicting depression in patients with Alzheimer’s disease(AD). Methods Ninety-six AD patients without depression were prospectively recruited and followed-up for 2 years. During follow-up, all patients were divided into the AD complicated with depression group(depression group) and AD without depression group(non-depression group) according to whether they were complicated by depression. Baseline data and serum 5-HT, IL-6, brain-derived neurotrophic factor(BDNF) and glucocorticoid(GC) levels at baseline were compared between two groups. The correlation between serum 5-HT and IL-6 levels and HAMD score was assessed by Pearson correlation analysis. The effect of serum 5-HT and IL-6 levels on depression in AD patients was evaluated by logistic regression analysis, and the receiver operating characteristic(ROC) curve was drawn. Results A total of 87 patients were included after 9 patients were excluded. The baseline data were comparable between two groups(all P > 0.05). In the depression group(n = 37), serum 5-HT level was significantly lower, whereas serum IL-6 level was significantly higher compared with those in the non-depression group(n = 50)(both P < 0.01). Serum 5-HT level was negatively correlated with HAMD score(r =-0.572, P < 0.01), whereas serum IL-6 level was positively correlated with HAMD score(r = 0.609, P < 0.01). Serum 5-HT level was a protective factor, whereas serum IL-6 level was a risk factor for depression in AD patients(both P < 0.05). The area under the ROC curve(AUC) for serum 5-HT level was 0.747, the sensitivity was 64.00%, and the specificity was 86.49%, respectively. The AUC of serum IL-6 level was 0.732, the sensitivity was 78.42%, and the specificity was 67.57%, respectively. The AUC constructed by combining serum 5-HT and IL-6 levels was 0.790, the sensitivity was 76.75%, and the specificity was 87.71%, respectively.Conclusions Abnormal serum 5-HT and IL-6 levels are correlated with depression in AD patients. These two combined can be used to predict the occurrence of depression in AD patients.
作者
胡孟谋
张霞军
欧阳和中
Hu Mengmou;Zhang Xiajun;Ouyang Hezhong(Clinical Laboratory,Danyang Hospital Affiliated to Nantong University,Danyang 212300,China;不详)
出处
《新医学》
CAS
2023年第1期35-39,共5页
Journal of New Medicine
基金
丹阳市人民医院科研立项(DRYK202105)。
