摘要
探讨注射用烟酸治疗冠心病(CHD)合并高脂血症患者的疗效及应用价值,并分析其对主要心血管不良事件(MACE)的影响。选取2021年8月—2023年8月在首都医科大学附属北京康复医院接受治疗的CHD合并高脂血症患者106例分为常规组(n=53)、观察组(n=53)。常规组给予常规基础治疗,观察组于此基础上给予注射用烟酸治疗。比较2组临床疗效、MACE及不良反应发生情况,及2组治疗前后心功能指标、心肌酶谱[肌酸激酶同工酶(CK-MB)、肌酸激酶(CK)、乳酸脱氢酶(LDH)]、BNP、血脂四项[甘油三酯(TG)、低密度脂蛋白(LDL-C)、总胆固醇(TC)、高密度脂蛋白(HDL-C)]水平。结果显示治疗3个月后,观察组患者总有效率高于常规组(94.34%vs 81.13%,P<0.05);与常规组相比,观察组左室舒张末内径(LVEDD)降低,左心室射血分数(LVEF)、心排血量(CO)升高(P<0.05);与常规组相比,观察组CK-MB、CK、LDH、BNP水平降低(P<0.05);与常规组相比,观察组TG、LDL-C、TC水平降低,HDL-C水平升高(P<0.05);2组不良反应发生率比较无明显差异(7.5%vs 5.66%,P>0.05);观察组MACE发生率低于常规组(5.88%vs 11.76%,P<0.05)。注射用烟酸联合常规基础治疗CHD合并高脂血症患者的疗效确切,可改善心功能,减轻心肌损伤,纠正心肌酶谱、血脂异常状态,减少MACE发生,且具有一定安全性。
To investigate the efficacy and application value of niacin for injection in the treatment of patients with coronary heart disease(CHD)complicated with hyperlipidemia,and to analyze its influence on major cardiovascular adverse events(MACE),a total of 106 CHD patients with hyperlipidemia treated in Beijing Rehabilitation Hospital of Capital Medical University from August 2021 to August 2023 were divided into conventional group(n=53)and observation group(n=53).The conventional group was given routine basic treatment,and the observation group was given niacin for injection on this basis.The clinical efficacy,MACE and the occurrence of adverse reactions were compared between the two groups.The cardiac function indicators,myocardial enzyme profile[creatine kinase isoenzyme(CK-MB),creatine kinase(CK),lactate dehydrogenase(LDH)],BNP,blood lipids[triglycerides(TG),low density lipoprotein(LDL-C),total cholesterol(TC),high density lipoprotein(HDL-C)]levels were compared between the two groups before and after treatment.The results showed that after 3 months of treatment,the total effective rate of observation group was higher than that of conventional group(94.34%vs 81.13%,P<0.05).Compared with conventional group,left ventricular end-diastolic diameter(LVEDD)was decreased,left ventricular ejection fraction(LVEF)and cardiac output(CO)were increased in observation group(P<0.05).Compared with the conventional group,the levels of CK-MB,CK,LDH and BNP in observation group were decreased(P<0.05).Compared with conventional group,the levels of TG,LDL-C and TC in observation group were decreased,and the levels of HDL-C were increased(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(7.50%vs 5.66%,P>0.05).The incidence of MACE in observation group was lower than that in conventional group(5.88%vs 11.76%,P<0.05).Niacin for injection combined with routine basic treatment of CHD patients with hyperlipidemia is effective,can improve cardiac function,alleviate myocardial damage,correct myocardial enzyme profile and dyslipidemia,reduce the occurrence of MACE,and has a certain safety.
作者
田红娇
万红叶
TIAN Hongjiao;WAN Hongye(Department of Pharmacy,Beijing Rehabilitation Hospital of Capital Medical University,Beijing 100144,China;Institute of Acupuncture Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《药物生物技术》
2025年第3期308-313,共6页
Pharmaceutical Biotechnology
基金
国家自然科学基金面上项目(No.82374284)。
关键词
冠心病
高脂血症
烟酸
心肌酶谱
疗效
心功能
主要心血管不良事件
Coronary heart disease
Hyperlipidemia
Niacin
Myocardial enzyme profile
Therapeutic effect
Heart function
Major cardiovascular adverse events
