摘要
牛结节性皮肤病(Lumpy skin disease,LSD)是一种牛的传染病,该病由牛结节性皮肤病病毒(Lumpy skin disease virus,LSDV)引起的牛全身性皮肤结节病变,给全世界养牛业造成严重的经济损失。目前,疫苗是预防该病最有效的手段,减毒活疫苗使用最为广泛,然而该疫苗会造成疫苗重组株流行。为开发安全有效的诊断试剂和疫苗,理解病毒致病机制,深入了解其分子结构和功能非常重要。论文对LSDV的基因组及功能研究做一综述,以期为LSD的防控和疫苗研制提供参考。
Lumpy skin disease(LSD)is an infectious disease of cattle.It can cause systemic nodular lesions on the skin of cattle by lumpy skin disease virus(LSDV),causing serious economic losses to the cattle industry around the world.At present,the most effective prevention control method for LSDV is vaccination,live attenuated vaccines are the most widely used,but it can cause the spread of vaccine-recombinant strains.In order to develop safe and effective diagnostic reagents and vaccines,it is very important to understand the pathogenesis of virus and its molecular structure and functions.In this paper,the genome and functions of LSDV are reviewed,with a view to provide references for the prevention and control of LSD and vaccine development.
作者
潘玉平
邓瑞雪
胡小慧
贾怀杰
安芳兰
刘学荣
PAN Yu-ping;DENG Rui-xue;HU Xiao-hui;JIA Huai-jie;AN Fang-lan;LIU Xue-rong(China Agricultural Vet.Bio.Science and Technology Co.LTD,Lanzhou,Gansu,730046,China;Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou,Gansu,730046,China)
出处
《动物医学进展》
北大核心
2025年第9期112-115,共4页
Progress In Veterinary Medicine
基金
甘肃省青年科技基金计划项目(21JR7RA741)。
关键词
牛结节皮肤病病毒
基因组
功能
Lumpy skin disease virus(LSDV)
Genome
Function
