摘要
间充质干细胞来源的外泌体(MSC-Exos)通过促进成骨及破骨细胞增殖、调节血管生成及局部微环境等机制,有望成为骨缺损修复的治疗策略。本文对MSC-Exos在骨缺损修复中的应用现状进行综述,并且讨论了目前已提出的优化方式,包括对间充质干细胞的预处理、靶向修饰,以提高MSC-Exos的生物活性,重点阐述了将MSC-Exos与支架材料结合以增强其局部递送效率和生物相容性,并探索其在骨缺损修复治疗中的潜在应用前景。
Mesenchymal stem cell-derived exosomes(MSC-Exos)are expected to become a promising therapeutic strategy for bone repair due to their ability to promote the proliferation of osteoblasts and osteoclasts,regulate angiogenesis,and modulate the local microenvironment.This review summarizes the current applications of MSC-Exos in bone defect repair and discusses the proposed optimization strategies,including the preconditioning of mesenchymal stem cell and targeted modifications to enhance the bioactivity of MSC-Exos.It particularly focuses on the combination of MSC-Exos with scaffold materials to improve their local delivery efficiency and biocompatibility,and explores the potential application prospects of MSC-Exos in bone defect treatment.
作者
王欣雨
李波儿
李飞飞
余钒源
叶玲
WANG Xinyu;LI Boer;LI Feifei;YU Fanyuan;YE Ling(State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China;Department of Endodontics,West China Stomatology Hospital,Sichuan University,Chengdu 610041,China;Department of Pediatric Dentistry,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)
出处
《口腔生物医学》
2025年第4期222-226,共5页
Oral Biomedicine
基金
四川省科技厅自然科学基金(25NSFSC2450,2023NSFSC-0563)。
关键词
间充质干细胞
外泌体
骨再生
组织工程
mesenchymal stem cell
exosomes
bone regeneration
tissue engineering
