摘要
目的:分析TBIL、γ-谷氨酰转肽酶(GGT)及Hb预测高胆红素血症新生儿并发急性胆红素脑病(ABE)的价值。方法:选取上饶市人民医院2021年9月—2024年9月收治的高胆红素血症新生儿80例,根据患儿随访1个月内是否发生ABE分为A组(未发生ABE)和B组(发生ABE),比较两组患儿肝功能指标(IBIL、TBIL、GGT、ALT),血常规指标[Hb、白蛋白(ALB)]及TBIL/ALB(B/A)值,并分析上述指标与高胆红素血症新生儿并发ABE的关系,同时采用ROC曲线分析肝功能指标与血常规指标对高胆红素血症新生儿并发ABE的预测价值。结果:共有31例(38.75%)高胆红素新生儿并发ABE。B组患儿IBIL、TBIL、GGT、ALT、Hb、B/A值显著高于A组,ALB显著低于A组,差异有统计学意义(P<0.05)。点二列相关性分析显示TBIL、GGT、Hb与高胆红素血症新生儿并发ABE呈正相关(r>0,P<0.05),但IBIL、ALT、ALB、B/A等指标与高胆红素血症新生儿并发ABE无明显相关性(P>0.05)。ROC曲线分析显示TBIL、GGT、Hb预测高胆红素血症新生儿发生ABE的AUC分别为0.769、0.683、0.657(P<0.05),其中TBIL的AUC最大。结论:高胆红素血症新生儿早期TBIL、GGT、Hb均与ABE的发生有密切关联,且三者对ABE的发生具有较高预测价值,其中以TBIL预测效果最佳。
Objective:To analyze the value of TBIL,gamma-glutamyl transpeptidase(GGT),and Hb in predicting acute bilirubin encephalopathy(ABE)in neonates with hyperbilirubinemia.Method:Eighty neonates with hyperbilirubinemia admitted to the Shangrao People's Hospital from September 2021 to September 2024 were selected,and divided into group A(without ABE)and group B(with ABE)according to whether ABE occurred during one month of follow-up.Liver function indicators(IBIL,TBIL,GGT,ALT),blood routine indicators[Hb and albumin(ALB)],and TBIL/ALB(B/A)values in the two groups were compared.The relationship between above indicators and the occurrence of ABE in neonates with hyperbilirubinemia was analyzed.The ROC curves were used to evaluate the predictive value of liver function indicators and blood routine indicators for ABE in neonates with hyperbilirubinemia.Result:A total of 31 cases(38.75%)neonates with hyperbilirubinemia developed ABE.IBIL,TBIL,GGT,ALT,Hb,and B/A in group B were significantly higher than those in group A,ALB was significantly lower than that in group A,with statistical significance(P<0.05).Point two-column correlation analysis showed that TBIL,GGT and Hb were positively correlated with ABE in neonates with hyperbilirubinemia(r>0,P<0.05).However,there were no significant correlation between IBIL,ALT,ALB,B/A with ABE in neonates with hyperbilirubinemia(P>0.05).The AUC of TBIL,GGT,and Hb for predicting ABE in neonates with hyperbilirubinemia were 0.769,0.683,and 0.657(P<0.05).The AUC of TBIL was the largest.Conclusion:Early TBIL,GGT,and Hb in neonates with hyperbilirubinemia are closely related to the occurrence of ABE.The three have high predictive value for ABE,especially TBIL.
作者
李欢
徐文慧
徐雯芳
阮毅
尹冬琴
LI Huan;XU Wenhui;XU Wenfang;RUAN Yi;YIN Dongqin(Department of Neonatology,Shangrao People's Hospital,Shangrao 334000,China;不详)
出处
《中国医学创新》
2025年第22期154-158,共5页
Medical Innovation of China
关键词
总胆红素
Γ-谷氨酰转肽酶
血红蛋白
高胆红素血症
急性胆红素脑病
Total serum bilirubin
Gamma-glutamyl transpeptidase
Hemoglobin
Hyperbilirubinemia
Acute bilirubin encephalopathy
