摘要
目的探讨葡萄糖6磷酸脱氢酶(G6PD)缺乏与新生儿高胆红素发生率及发病时间的关系,为高胆的临床诊断及治疗提供科学依据。方法对2008年1月至2009年12月在韶关市妇幼保健院分娩的活产新生儿采用荧光斑点法对其进行G6PD筛查,对G6PD缺乏的患儿,按姓别分组调查其高胆发生率及发病时间。结果 G6PD缺乏的患儿高胆发生率显著高于对照组新生儿;男性高胆发生率显著高于女性;G6PD缺乏的患儿的发病时间主要在生后一用周内。结论 G6PD缺乏为新生儿高胆的重要病因,发病率男性高于女性,发病高峰在出生2～4天,对G6PD缺乏的高胆患儿进行早期干预,能有效减轻G6PD缺乏新生儿溶血的程度和避免发生核黄疸。
Objective：To investigate the relationship between glucose-6-phosphatedehydrogenase（G6PD）.Deficiency and the incidence and the incident time of neonatal hyperbibirubinemia and provide the science evdience for clinial diagnosis and teeatment.Methods： Neonatal who born in our hospital in 2008.1-2009.12 were collected for the G-6-PD.Screening with fluoresence spot test.The children lack of G-6-PD activity were divided by sex and investigated the incidence and the incidence time of hyperbibirubinemia.Results： The incidence of hyperbibirubinemia in children with G-6-PD deficiency was significantly higher than that in the newborn;In the children with G-6-PD deficiency,the incidence of hyperbibirubinemia in male was significantly higher than that in women;The incident time of hyperbibirubinemia in children with G-6-PD deficiency mainly occurred in one week after the birth.Conclusion：G-6-PD deficiency is the important cause of neonatal hyperbibirubinemia.The incidence of hyperbibirubinemia in male was higher than that in women.The peak incident time in 2-4 days after the birth.To intervene for G-6-PD deficiency early can reduce the degree for hemolysis and avoid the bilirubin encephalopathy.
出处
《中国优生与遗传杂志》
2011年第9期97-98,共2页
Chinese Journal of Birth Health & Heredity
