摘要
目的分析血栓通注射液联合丁苯酞治疗急性脑梗死的临床疗效及对降低残障率的影响。方法便利选取2023年1月—2024年12月淮南东方医院集团凤凰医院收治的100例急性脑梗死患者为研究对象,根据不同药物治疗分为对照组(50例,丁苯酞治疗)和观察组(50例,血栓通注射液联合丁苯酞治疗)。比较两组患者的临床疗效、血脂指标、神经功能、残疾程度和不良反应。结果观察组治疗总有效率高于对照组,观察组血脂指标水平优于对照组,差异均有统计学意义(P均<0.05)。治疗3、6个月后,观察组神经功能评分分别为(12.93±3.72)分、(8.31±2.64)分,均低于对照组的(15.62±3.55)分、(10.29±3.11)分,观察组改良Rankin量表评分分别为(3.12±0.76)分、(2.08±0.54)分,均优于对照组的(4.36±0.82)分、(2.84±0.69)分,差异均有统计学意义(t=3.699,3.432,7.842,6.133;P均<0.05)。治疗6个月后,两组患者均无死亡,观察组残障率低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论针对急性脑梗死患者进行血栓通注射液联合丁苯酞治疗的临床效果显著,能有效改善患者的血脂指标和神经功能,进一步降低患者的残障率,且安全性较高。
Objective To analyze the clinical efficacy of thrombus injection combined with butylphthalide in the treat-ment of acute cerebral infarction and its effect on reducing disability rate.Methods A total of 100 patients with acute cerebral infarction admitted to Huainan Oriental Hospital Group,Phoenix Hospital from January 2023 to December 2024 were conveniently selected as the research objects.According to different drug treatments,they were divided into control group(50 cases,butylphthalide treatment)and observation group(50 cases,thrombus injection combined with butylphthalide treatment).The clinical efficacy,blood lipid index,neurological function,disability degree and ad-verse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group,the levels of blood lipid indicators in the observation group were better than those in the control group,differences were statistically significant(all P<0.05).After 3 and 6 months of treat-ment,the neurological function scores in the observation group were 12.93±3.72 and 8.31±2.64,which were lower than 15.62±3.55 and 10.29±3.11 in the control group,Modified Rankin Scale scores in the observation group were 3.12±0.76 and 2.08±0.54,which were better than 4.36±0.82 and 2.84±0.69 in the control group,differences were sta-tistically significant(t=3.699,3.432,7.842,6.133;all P<0.05).After 6 months of treatment,no deaths occurred in ei-ther group,and the disability rate in the observation group was lower than that in the control group,difference was sta-tistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions be-tween the two groups(P>0.05).Conclusion The clinical effect of thrombus injection combined with butylphthalide in patients with acute cerebral infarction is significant.It can effectively improve the blood lipid index and neurological function of patients,further reduce the disability rate of patients,and has high safety.
作者
李庭
LI Ting(Department of Neurology,Huainan Oriental Hospital Group,Phoenix Hospital,Huainan 232100,Anhui,China)
出处
《系统医学》
2025年第12期119-123,共5页
Systems Medicine
关键词
急性脑梗死
血栓通注射液
丁苯酞
临床疗效
残障率
Acute cerebral infarction
Thrombus injection
Butylphthalide
Clinical efficacy
Disability rate
