摘要
目的探究成人1型糖尿病(diabetes mellitus type 1,T1DM)患者应用胰岛素治疗中加入西格列汀的效果。方法目的选取2021年1月—2023年12月新沂市人民医院收治的76例成人T1DM患者作为研究对象。根据药物治疗方案不同分为对照组(胰岛素治疗)、观察组(胰岛素治疗基础上加入西格列汀),各38例。比较两组患者血糖水平、胰岛素用量及体重指数、不良反应发生率和低血糖发生率。结果治疗90 d后,观察组空腹血糖、餐后2 h血糖、糖化血红蛋白水平分别为(5.71±1.04)mmol/L、(8.61±1.86)mmol/L、(6.02±1.01)%,低于对照组的(6.22±1.06)mmol/L、(10.07±1.85)mmol/L、(6.55±1.22)%,差异均有统计学意义(t=2.117,3.431,2.063;P均<0.05)。治疗90 d后,观察组胰岛素用量更少,差异均有统计学意义(P均<0.05)。观察组和对照组体重指数、不良反应总发生率相比,差异均无统计学意义(P均>0.05),但观察组低血糖发生率低于对照组,差异有统计学意义(P<0.05)。结论胰岛素治疗成人T1DM基础上联用西格列汀,血糖水平控制效果显著,可减少胰岛素用量并降低低血糖发生风险且安全性良好。
Objective To explore the effect of sitagliptin on insulin therapy in adult patients with type 1 diabetes mel-litus(T1DM).Methods A total of seventy-six adult patients with T1DM admitted to Xinyi People′s Hospital from January 2021 to December 2023 were purposefully selected as the research objects.According to different drug treat-ment schemes,they were divided into control group(insulin treatment)and observation group(sitagliptin on the basis of insulin treatment),thirty-eight cases in each group.The blood glucose level,insulin dosage and body mass index,incidence of adverse reactions and incidence of hypoglycemia were compared between the two groups.Results After 90 days of treatment,the levels of fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin in the observation group were(5.71±1.04)mmol/L,(8.61±1.86)mmol/L and(6.02±1.01)%,respectively,which were lower than(6.22±1.06)mmol/L,(10.07±1.85)mmol/L and(6.55±1.22)%in the control group,and the differences were statistically significant(t=2.117,3.431,2.063;all P<0.05).After 90 days of treatment,the dosage of insulin in the observation group was less,and the difference was statistically significant(all P<0.05).There was no significant difference in body mass index and total incidence of adverse reactions between the observation group and the control group(all P>0.05),but the incidence of hypoglycemia in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Insulin combined with sitagliptin in the treatment of adult T1DM has a significant effect on blood glucose level control,which can reduce insulin dosage and reduce the risk of hypoglycemia with good safety.
作者
赵情
高庆
杨帅
耿直
ZHAO Qing;GAO Qing;YANG Shuai;GENG Zhi(Department of Endocrinology,Xinyi People′s Hospital,Xinyi 221400,Jiangsu,China)
出处
《系统医学》
2025年第12期107-110,共4页
Systems Medicine
