摘要
目的探讨多标记后延迟(PLD)时间动脉自旋标记(ASL)成像评估不同血压控制水平的高血压患者脑血流储备(CVR)的价值。方法选取经临床确诊的62例高血压住院患者,均行ASL、T_(1)WI、T_(2)WI、Flair及DWI检查。根据血压控制水平将患者分为血压控制不良组(G1组)36例和血压控制良好组(G2组)26例。测量两组额叶、顶叶、颞叶、枕叶、岛叶、豆状核、小脑、丘脑及脑桥脑血流量(CBF)。采用重复测量资料的方差分析比较两组同一区域不同PLD的CBF差异,并比较两组间同一区域CBF_(PLD)差异。结果G1组各脑叶、豆状核、小脑的CBF_(2.5)及CBF_(2.0)均高于CBF_(1.5),差异有统计学意义(P<0.001),但CBF_(2.5)、CBF_(2.0)组间差异无统计学意义(P>0.05);G2组各脑叶、豆状核、小脑的CBF_(2.5)及CBF_(2.0)均高于CBF_(1.5),差异有统计学意义(P<0.001),且CBF_(2.5)均高于CBF_(2.0),差异有统计学意义(P<0.05);G2组丘脑、脑桥CBF_(2.5)均高于CBF_(1.5),差异有统计学意义(P<0.05)。G1组各脑叶、豆状核、小脑的CBF_(1.5)、CBF_(2.0)及CBF_(2.5)均低于G2组,差异有统计学意义(P<0.05);G1组丘脑、脑桥CBF_(2.5)均低于G2组,差异有统计学意义(P分别为0.008、0.025),但两组间丘脑、脑桥CBF_(1.5)和CBF_(2.0)比较,差异无统计学意义(P>0.05)。结论血压控制良好者全脑CBF较高且脑血流代偿充足,多PLD ASL成像可为临床高血压管理及脑血管疾病预防提供重要依据。
Objective To investigate the application value of multiple post-labeling delay(PLD)arterial spin labeling(ASL)imaging in evaluating cerebrovascular reserve in hypertensive patients with different blood pressure control levels.Methods Sixty-two patients with hypertension were examined on ASL,T1WI,T2WI,Flair and DWI.According to the blood pressure control levels,patients were divided into poorly controlled blood pressure group(G1 group)and well controlled blood pressure group(G2 group).Cerebral blood flow(CBF)was measured in frontal lobe,parietal lobe,temporal lobe,occipital lobe,insula,lentiform nucleus,cerebellum,thalamus,and pons.The difference of CBF in different PLD in the same region of G1 group and G2 group was compared by repeated measure analysis of variance,and the CBFPLD differences in the same region between G1 and G2 groups were compared.Results Among the 62 patients,36 were in the G1 group and 26 were in the G2 group.Pairwise comparison results showed that CBF2.5 and CBF2.0 were higher than CBF1.5 in each lobe,lentiform nucleus,and cerebellum in the G1 group(P<0.001),while,there was no significant difference between CBF2.5 and CBF2.0 in those regions(P>0.05).CBF2.5 and CBF2.0 were higher than CBF1.5 in each lobe,lentiform nucleus,and cerebellum in the G2 group(P<0.001),and CBF2.5 was higher than CBF2.0 in those regions(P<0.05).CBF2.5 was higher than CBF1.5 in thalamus and pons in the G2 group(P<0.05).CBF1.5,CBF2.0 and CBF2.5 in each lobe,lentiform nucleus,and cerebellum in the G1 group were lower than those in the G2 group(P<0.05).CBF2.5 in thalamus and pons in the G1 group were lower than those in the G2 group(P values were 0.008 and 0.025,respectively),while CBF1.5 and CBF2.0 in the thalamus and pons were not significantly different between the two groups(P>0.05).Conclusion Compared with the poorly controlled blood pressure group,the well-controlled blood pressure group had higher CBF and sufficient cerebral blood flow compensation,and multi-PLD ASL could provide important basis for clinical hypertension management and prevention of cerebrovascular diseases.
作者
李晶龙
薛永杰
李奕杉
赵凡惠
LI Jinglong;XUE Yongjie;LI Yishan;ZHAO Fanhui(Department of Medical Imaging Center,Xi'an No.3 Hospital,the Affiliated Hospital of Northwest University,Xi'an 710018,China)
出处
《医学影像学杂志》
2025年第7期9-13,共5页
Journal of Medical Imaging
基金
陕西省西安市卫生健康委员会科研项目(编号:2024yb06)。
关键词
高血压
动脉自旋标记
磁共振成像
脑血流量
Hypertension
Arterial spin labeling
Magnetic resonance imaging
Cerebral blood flow
