期刊文献+

高血压患者脑血流动力学改变特征的MRI研究 被引量:2

The study of hemodynamics in brain of patients with hypertension by combining MR perfusion imaging with an acetazolamide challenge
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摘要 目的:利用磁共振(MR)灌注成像(PWI)结合乙酰唑胺(ACZ)负荷试验评估高血压患者脑血流动力学改变的特征。方法:对13例无血管狭窄的高血压患者和12例正常对照在口服乙酰唑胺前后进行常规MR检查和PWI检查,测量两组受检者双侧尾状核、豆状核、额上回、颞上回、丘脑和楔叶的血流平均通过时间(MTT)、局部脑血容量(rCBV)并计算局部脑血流量(rCBF)后进行比较。结果:(1)ACZ负荷前:高血压组双侧尾状核、额上回、颞上回、丘脑和楔叶的MTT短于正常对照组(P<0.05),但豆状核的MTT与对照组比较无显著差异;两组受检者各兴趣区(ROI)的rCBV及rCBF无显著差异;(2)ACZ负荷后:高血压组豆状核的MTT长于对照组(P<0.05),其余各ROI的MTT相比较无显著差异;两组受检者各ROI的rCBV及rCBF之间无统计学差异。结论:高血压患者在发生血管狭窄之前,其脑血流动力学已经发生改变,而且各部位的改变程度不一致,豆状核可能是血液动力学改变发生最早的部位之一。
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2008年第11期2268-2271,共4页 Chinese Journal of Pathophysiology
基金 广东省自然科学基金资助项目(No.021154)
关键词 磁共振灌注成像 乙酰唑胺 高血压 血流动力学 MR perfusion-weighted imaging Acetazolamide Hypertension Hemodynamics
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参考文献12

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共引文献47

同被引文献30

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