摘要
乙型肝炎病毒(HBV)感染是发生肝细胞癌(HCC)的主要病因之一。尽管疫苗接种和抗病毒治疗降低了部分地区的HBV感染率,但HBV相关HCC(HBV-HCC)的发病率仍较高。因此,深入研究HBV-HCC的致癌机制,不仅有助于阐明病毒驱动肿瘤发生的关键分子事件,还可为早期诊断、风险分层及靶向治疗提供理论依据。本文从HBV蛋白和基因变异、肝组织基因表达、病毒基因整合、细胞信号传导途径、肝脏干细胞转化恶性转化与异质性、宿主遗传因素及器官内铁代谢异常等多方面探究HBV-HCC的致癌机制,供临床和科研参考。
Hepatitis B virus(HBV)infection is one of the leading causes of hepatocellular carcinoma(HCC).Although vaccination and antiviral therapy have reduced HBV infection rates in some regions,the incidence of HBV-associated HCC(HBV-HCC)remains high.Therefore,in-depth research into the carcinogenic mechanisms of HBV-HCC not only helps elucidate the key molecular events by which the virus drives tumorigenesis but also provides a theoretical basis for early diagnosis,risk stratification,and targeted therapy.This article explores the carcinogenic mechanisms of HBV-HCC from multiple perspectives,including HBV proteins and genetic variations,gene expression in liver tissue,viral genome integration,cell signaling pathways,malignant transformation and heterogeneity of liver stem cells,host genetic factors,and intra-organ iron metabolism abnormalities,offering insights for clinical and scientific research.
作者
马亦林
Ma Yilin(Department of Infectious Diseases,State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China)
出处
《中华临床感染病杂志(中英文)》
北大核心
2025年第2期96-117,共22页
Chinese Journal of Clinical Infectious Diseases
关键词
肝细胞癌
乙型肝炎病毒
致癌机制
Hepatocellular carcinoma
Hepatitis B virus
Carcinogenic mechanisms
